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Previous Volume 341:372-373 July 29, 1999 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Tuomilehto and colleagues present a post hoc analysis (March 4 issue)¹ of a trial of nitrendipine-based treatment for older patients with isolated systolic hypertension.² The authors evaluated the outcome in patients with diabetes, a group that accounted for 10 percent of the population originally studied. It is difficult and often misleading to make meaningful conclusions on the basis of an analysis of small subgroups chosen after the study design has been established and the results recorded. However, the authors conclude that antihypertensive treatment with dihydropyridine calcium-channel blockers may be particularly helpful for patients with diabetes, not harmful . . . [Full Text of this Article]

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