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Previous Volume 341:451-452 August 5, 1999 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: El-Serag and Mason (March 11 issue)¹ report an increase in the incidence of hepatocellular carcinoma in the United States and suggest that the hepatitis B virus (HBV) and hepatitis C virus are the cause. Similar trends in the incidence of hepatocellular carcinoma have been reported worldwide.² We have also found an appreciable increase in the age-standardized incidence of hepatocellular carcinoma in Göteborg, Sweden, from 2.3 cases per 100,000 population to 3.6 cases during a 22-year period.³ However, when we used a Poisson model,⁴ we found no significant increase in incidence after adjusting for age, either in men . . . [Full Text of this Article]

References

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• Shibuya, K., Yano, E. (2005). Regression analysis of trends in mortality from hepatocellular carcinoma in Japan, 1972-2001. Int J Epidemiol 34: 397-402 [Abstract] [Full Text]  
• El-Serag, H. B., Davila, J. A., Petersen, N. J., McGlynn, K. A. (2003). The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An Update. ANN INTERN MED 139: 817-823 [Abstract] [Full Text]  
• Kim, W., Oe Lim, S., Kim, J.-S., Ryu, Y. H., Byeon, J.-Y., Kim, H.-J., Kim, Y.-I., Heo, J. S., Park, Y. M., Jung, G. (2003). Comparison of Proteome between Hepatitis B Virus- and Hepatitis C Virus-Associated Hepatocellular Carcinoma. Clin. Cancer Res. 9: 5493-5500 [Abstract] [Full Text]