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Figure 1. A 39-year-old man with homozygous familial hypercholesterolemia because of a G C mutation at the acceptor-splice site of intron 7 of the low-density lipoprotein (LDL) receptor had undergone coronary-artery bypass grafting at the age of 29 years and carotid endarterectomy at the ages of 38 and 39 years. His plasma LDL cholesterol level ranged from 463 to 500 mg per deciliter (12 to 13 mmol per liter). Twice-monthly treatment with selective LDL filtration, with the use of apheresis and a macromolecular exclusion filter (pore size, approximately 2x106 daltons), was begun and was subsequently supplemented with . . . [Full Text of this Article] |