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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 341:512-519 August 12, 1999 Number 7
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Case 24-1999— Neurologic Disorder in a 65-Year-Old Man after Treatment of Colon Cancer
Lawrence D. Recht, and James M. Primavera

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Presentation of Case

A 65-year-old man was admitted to the hospital because of impaired cognition and a gait disorder.

The patient had been well until 10 months earlier, when he began to have a diffuse, mild, nonprogressive headache that was continuous. Six months before admission, hematochezia led to the discovery of carcinoma of the sigmoid colon. One month later, the tumor was resected at another hospital; there was no evidence of hepatic metastasis. Microscopical examination of the specimen revealed adenocarcinoma, grade 2 of 4, that had penetrated the serosa and metastasized to 1 of 12 pericolonic lymph nodes. An induction course of fluorouracil . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnosis

Dr. Lawrence D. Recht's Diagnosis

Pathological Discussion

Anatomical Diagnosis

Addendum

References



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