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Editorial
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Volume 341:524-526 August 12, 1999 Number 7
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Prophylactic Cranial Irradiation and Small-Cell Lung Cancer

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 by Aupérin, A.
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Small-cell lung cancer, the type of lung cancer most strongly associated with tobacco exposure, accounts for 20 to 25 percent of all cases of lung cancer (approximately 45,000 new cases per year in the United States). The majority of patients are treated with combination chemotherapy (etoposide and cisplatin) for four to six months, with or without concurrent thoracic irradiation. The median survival for patients who are not treated is only 6 to 12 weeks, whereas for patients treated with combination chemotherapy, the median survival is 10 to 12 months. For patients with extensive disease (disease extending beyond one hemithorax or . . . [Full Text of this Article]

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