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Volume 341:549-555 August 19, 1999 Number 8 Next

	Full Text PDF Editorial by Utiger, R. D. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Herzmann, C. PubMed Citation

ABSTRACT

Background When thyroid deficiency occurs simultaneously in a pregnant woman and her fetus, the child's neuropsychological development is adversely affected. Whether developmental problems occur when only the mother has hypothyroidism during pregnancy is not known.

Methods In 1996 and 1997, we measured thyrotropin in stored serum samples collected from 25,216 pregnant women between January 1987 and March 1990. We then located 47 women with serum thyrotropin concentrations at or above the 99.7th percentile of the values for all the pregnant women, 15 women with values between the 98th and 99.6th percentiles, inclusive, in combination with low thyroxine levels, and 124 matched women with normal values. Their seven-to-nine-year-old children, none of whom had hypothyroidism as newborns, underwent 15 tests relating to intelligence, attention, language, reading ability, school performance, and visual–motor performance.

Results The children of the 62 women with high serum thyrotropin concentrations performed slightly less well on all 15 tests. Their full-scale IQ scores on the Wechsler Intelligence Scale for Children, third edition, averaged 4 points lower than those of the children of the 124 matched control women (P=0.06); 15 percent had scores of 85 or less, as compared with 5 percent of the matched control children. Of the 62 women with thyroid deficiency, 48 were not treated for the condition during the pregnancy under study. The full-scale IQ scores of their children averaged 7 points lower than those of the 124 matched control children (P=0.005); 19 percent had scores of 85 or less. Eleven years after the pregnancy under study, 64 percent of the untreated women and 4 percent of the matched control women had confirmed hypothyroidism.

Conclusions Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted.

Source Information

From the Foundation for Blood Research, Scarborough, Me. (J.E.H., G.E.P., W.C.A., J.R.W., G.J.K., J.G., C.E.O.); the New England Newborn Screening Program, Jamaica Plain, Mass. (M.L.M., R.J.H.); Children's Hospital, Boston (S.E.W.); Beth Israel Deaconess Medical Center, Boston (J.D.F.); and Dartmouth Medical School, Hanover, N.H. (R.Z.K.).

Address reprint requests to Dr. Haddow at the Foundation for Blood Research, 69 U.S. Rte. 1, Scarborough, ME 04074.

Full Text of this Article

Related Letters:

Maternal Thyroid Deficiency during Pregnancy and Subsequent Neuropsychological Development of the Child
Herzmann C., Torrens J. K., de Escobar G. M., del Rey F. E., Fukushi M., Honma K., Fujita K., Hollowell J. G., Garbe P. L., Miller D. T., Haddow J. E., Klein R. Z., Mitchell M., Utiger R. D.
Extract | Full Text  
N Engl J Med 1999; 341:2015-2017, Dec 23, 1999. Correspondence

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• Ogilvy-Stuart, A L (2002). Neonatal thyroid disorders. Arch. Dis. Child. Fetal Neonatal Ed. 87: F165-171 [Abstract] [Full Text]  
• Stagnaro-Green, A. (2002). Postpartum Thyroiditis. J. Clin. Endocrinol. Metab. 87: 4042-4047 [Full Text]  
• Moreno, J. C., Bikker, H., Kempers, M. J.E., van Trotsenburg, A.S. P., Baas, F., de Vijlder, J. J.M., Vulsma, T., Ris-Stalpers, C. (2002). Inactivating Mutations in the Gene for Thyroid Oxidase 2 (THOX2) and Congenital Hypothyroidism. NEJM 347: 95-102 [Abstract] [Full Text]  
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• Forrest, D. (2002). Editorial: Twists in the Tail--Change-of-Function Mutations in Thyroid Hormone Receptors. Endocrinology 143: 2466-2468 [Full Text]  
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• Calvo, R. M., Jauniaux, E., Gulbis, B., Asuncion, M., Gervy, C., Contempre, B., Morreale de Escobar, G. (2002). Fetal Tissues Are Exposed to Biologically Relevant Free Thyroxine Concentrations during Early Phases of Development. J. Clin. Endocrinol. Metab. 87: 1768-1777 [Abstract] [Full Text]  
• Zhou, T., Taylor, M. M., DeVito, M. J., Crofton, K. M. (2002). Developmental Exposure to Brominated Diphenyl Ethers Results in Thyroid Hormone Disruption. Toxicol Sci 66: 105-116 [Abstract] [Full Text]  
• Dunn, J. T. (2002). Guarding our Nation's Thyroid Health. J. Clin. Endocrinol. Metab. 87: 486-488 [Full Text]  
• Dashe, J. S., Cunningham, F. G., Mazziotti, A., Press, M., Cooper, D. S. (2001). Subclinical Hypothyroidism. NEJM 345: 1855-1856 [Full Text]  
• Muller, A. F., Drexhage, H. A., Berghout, A. (2001). Postpartum Thyroiditis and Autoimmune Thyroiditis in Women of Childbearing Age: Recent Insights and Consequences for Antenatal and Postnatal Care. Endocr. Rev. 22: 605-630 [Abstract] [Full Text]  
• McDermott, M. T., Ridgway, E. C. (2001). Subclinical Hypothyroidism Is Mild Thyroid Failure and Should be Treated. J. Clin. Endocrinol. Metab. 86: 4585-4590 [Full Text]  
• Shankar, P, Kilvert, A, Fox, C (2001). Changing thyroid status related to pregnancy. Postgrad. Med. J. 77: 591-592 [Abstract] [Full Text]  
• Toft, A. D. (2001). Subclinical Hyperthyroidism. NEJM 345: 512-516 [Full Text]  
• Cooper, D. S. (2001). Subclinical Hypothyroidism. NEJM 345: 260-265 [Full Text]  
• Yen, P. M. (2001). Physiological and Molecular Basis of Thyroid Hormone Action. Physiol. Rev. 81: 1097-1142 [Abstract] [Full Text]  
• Smallridge, R. C., Ladenson, P. W. (2001). Hypothyroidism in Pregnancy: Consequences to Neonatal Health. J. Clin. Endocrinol. Metab. 86: 2349-2353 [Full Text]