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Previous Volume 342:730-732 March 9, 2000 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The first comprehensive description of a syndrome comprising laxity and fragility of the skin associated with hypermobility of the large joints was published in 1892 by Tschernogobow¹ in Moscow. With remarkable insight, he interpreted the cause of the phenotype as a systemic defect in connective tissue. However, as is common in medicine, those who came later are immortalized in the eponym, in this case Ehlers² and Danlos,³ Danish and French dermatologists, respectively, who published their observations independently in the first decade of the 20th century.

The familial nature of these clinical associations was demonstrated in 1949,⁴ and soon thereafter Jansen⁵ . . . [Full Text of this Article]

References

Related Letters:

Ehlers–Danlos Syndrome Type IV
Barabas A. P., Pinto Y. M., Pals G., Zijlstra J. G., Tulleken J. E., Byers P. H., Schwarze U., Pepin M., Pyeritz R. E.
Extract | Full Text  
N Engl J Med 2000; 343:366-368, Aug 3, 2000. Correspondence

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