Patients infected with human immunodeficiency virus type 1 (HIV-1)are susceptible to neoplasms, including Kaposi's sarcoma, non-Hodgkin'slymphoma, and anal and cervical carcinoma.1,2,3,4,5 Some ofthese neoplasms have been associated with oncogenic infectiousagents such as human herpesvirus 8 (HHV-8), EpsteinBarrvirus (EBV), human T-cell leukemialymphoma virus typeI (also known as human T-cell lymphotropic virus type I; HTLV-I),and the human papillomavirus (HPV).1,2,3,4,5 Presumably, theimmunosuppression caused by HIV-1 allows for the expansion ofvirally transformed cells and the development of cancer.
HTLV-I and human T-cell lymphotropic virus type II (HTLV-II)are oncogenic retroviruses.6,7 HTLV-I infects CD4+ T cells . . . [Full Text of this Article]
Case Report
Methods
Skin Biopsy
Peripheral Blood
Establishment and Characterization of a T-Cell Line Derived from the Peripheral Blood
Results
Discussion
Source Information
From the Departments of Medicine (B.P., D.D., S.D., J.L.) and Pathology (A.U., R.H.), State University of New York Upstate Medical University, Syracuse; and Cellular Products, Buffalo, N.Y. (L.P.).
Address reprint requests to Dr. Poiesz at the Department of Medicine, SUNY Health Science Center at Syracuse, 750 E. Adams St., Syracuse, NY 13210.
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