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Original Article
Brief Report
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Volume 342:930-936 March 30, 2000 Number 13
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HTLV-II–Associated Cutaneous T-Cell Lymphoma in a Patient with HIV-1 Infection
Bernard Poiesz, M.D., Dipak Dube, Ph.D., Syamalima Dube, Ph.D., Jayne Love, M.D., Lawrence Papsidero, Ph.D., Aysegul Uner, M.D., Ph.D., and Robert Hutchinson, M.D.

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Patients infected with human immunodeficiency virus type 1 (HIV-1) are susceptible to neoplasms, including Kaposi's sarcoma, non-Hodgkin's lymphoma, and anal and cervical carcinoma.1,2,3,4,5 Some of these neoplasms have been associated with oncogenic infectious agents such as human herpesvirus 8 (HHV-8), Epstein–Barr virus (EBV), human T-cell leukemia–lymphoma virus type I (also known as human T-cell lymphotropic virus type I; HTLV-I), and the human papillomavirus (HPV).1,2,3,4,5 Presumably, the immunosuppression caused by HIV-1 allows for the expansion of virally transformed cells and the development of cancer.

HTLV-I and human T-cell lymphotropic virus type II (HTLV-II) are oncogenic retroviruses.6,7 HTLV-I infects CD4+ T cells . . . [Full Text of this Article]

Case Report

Methods

Skin Biopsy

Peripheral Blood

Establishment and Characterization of a T-Cell Line Derived from the Peripheral Blood

Results

Discussion


Source Information

From the Departments of Medicine (B.P., D.D., S.D., J.L.) and Pathology (A.U., R.H.), State University of New York Upstate Medical University, Syracuse; and Cellular Products, Buffalo, N.Y. (L.P.).

Address reprint requests to Dr. Poiesz at the Department of Medicine, SUNY Health Science Center at Syracuse, 750 E. Adams St., Syracuse, NY 13210.

References


Related Letters:

HIV-1 and an HTLV-II–Associated Cutaneous T-Cell Lymphoma
Guitart J., Poiesz B. J., Dube D., Hutchison R.
Extract | Full Text  
N Engl J Med 2000; 343:303-304, Jul 27, 2000. Correspondence

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