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Previous Volume 342:969-970 March 30, 2000 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although thiazide diuretics and beta-blockers are often used as first-line therapy in patients with hypertension, including those with diabetes mellitus,¹ the possibility that these drugs may promote glucose intolerance remains a concern.^{2,3,4,5,6,7,8,9,10} Short-term metabolic studies, as well as epidemiologic studies and clinical trials, suggested a causal link between the use of thiazide diuretics and the subsequent development of type 2 diabetes.^{3,4,5,6,7,8,9,10} However, those studies were compromised by small numbers of patients, relatively short follow-up periods, changing definitions of new-onset diabetes, lack of adequate comparison groups, selection criteria that lessened the extent to which the results could be generalized, and study . . . [Full Text of this Article]

References

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