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Previous Volume 342:983 March 30, 2000 Number 13 Next

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Edited by Stanley B. Prusiner. 794 pp., illustrated. Cold Spring Harbor, N.Y., Cold Spring Harbor Laboratory Press, 1999. $125. ISBN 0-87969-547-1.

Prion-related diseases constitute a unique category of illnesses that can be inherited, infectious, or sporadic. The ongoing saga of efforts to unravel the pathogenesis of prion diseases is one of the most fascinating accounts in recent medical science. This group of diseases seems to have dispelled two long-held convictions: that nucleic acids are always needed to encode biologic information transmitted from generation to generation, and that a protein of a given amino acid sequence can give rise only to one tertiary structure of biologic importance. Prion Biology and Diseases provides an authoritative review of the work on prions. The book . . . [Full Text of this Article]

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