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Previous Volume 342:1027-1038 April 6, 2000 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1872, Moritz Kaposi, a Hungarian dermatologist, described five men with aggressive "idiopathic multiple pigmented sarcomas of the skin."¹ One patient died of gastrointestinal bleeding 15 months after the initial appearance of the skin lesions, and an autopsy showed visceral lesions in the lungs and the gastrointestinal tract. Subsequently, other investigators described four clinical variants of Kaposi's sarcoma that had identical histologic features but developed in specific populations and had different sites of involvement and rates of progression (Table 1). In the light of recent discoveries regarding the viral pathogenesis of Kaposi's sarcoma, these variants most likely represent . . . [Full Text of this Article]

Clinical Variants of Kaposi's Sarcoma

Classic Kaposi's Sarcoma

Endemic Kaposi's Sarcoma

Immunosuppression-Associated, or Transplantation-Associated, Kaposi's Sarcoma

Epidemic, or AIDS-Associated, Kaposi's Sarcoma

Kaposi's Sarcoma–Associated Herpesvirus

Epidemiology of Kaposi's Sarcoma and KSHV

KSHV Infection in Humans

Rates of Infection in Various Populations

Transmission

Natural History of KSHV Infection

Treatment

Classic Kaposi's Sarcoma

            Radiation Therapy

            Systemic or Combination Therapy

Endemic Kaposi's Sarcoma

Immunosuppression-Associated Kaposi's Sarcoma

Epidemic Kaposi's Sarcoma

            Radiation Therapy

            Cytotoxic Drugs

            Biologic Agents

            Interferon in Combination with Antiretroviral Therapy

            Experimental Therapies

Prevention

Source Information

From the Departments of Medicine (K.A.) and Pathology (Y.C.), Columbia University College of Physicians and Surgeons, New York.

Address reprint requests to Dr. Chang at P&S14-442, Department of Pathology, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032.

References

Related Letters:

Kaposi's Sarcoma
Washenik K., Clark-Loeser L., Friedman-Kien A., Simonart T., Vooren J.-P. V., Meuris S., Mazzone A., Ottini E., Paulli M., Antman K., Chang Y.
Extract | Full Text  
N Engl J Med 2000; 343:581-584, Aug 24, 2000. Correspondence

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