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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 342:1110-1117 April 13, 2000 Number 15
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Case 11-2000— A 74-Year-Old Man with Memory Loss, Language Impairment, and Personality Changes
John H. Growdin, and James M. Primavera

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Presentation of Case

A 74-year-old man was referred to the Memory and Movement Disorders Unit of this hospital because of progressive memory loss and personality changes.

The patient had been well until three years earlier, when his wife observed that he was becoming forgetful. There was subsequent progressive impairment of memory, occasional urinary incontinence, and inappropriate behavior, such as recitation of poorly constructed limericks in public. When speaking he made paraphasic errors, such as "I cannot button my tie." Although he continued to work in an intellectually demanding profession, his colleagues noted that he made many errors in judgment. Laboratory tests were negative. . . . [Full Text of this Article]

Differential Diagnosis

Clinical Diagnosis

Dr. John H. Growdon's Diagnosis

Pathological Discussion

Anatomical Diagnosis

References




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