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Previous Volume 342:1135-1137 April 13, 2000 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Berry, R. J. Related Article by Botto, L. D.

To the Editor: Botto et al. (Nov. 11 issue)¹ fail to represent fairly the work of Smithells and associates² and the subsequent delayed response by public health authorities to the important discovery that folic acid supplementation prevents a substantial percentage of neural-tube defects. Botto et al. claim that because Smithells and colleagues "had not been permitted to randomly assign the use of the multivitamin among participants in their study, their finding did not lead to any public health action" until the results of randomized studies were published a decade later. In fact, Smithells and colleagues had earlier reported the association . . . [Full Text of this Article]

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