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Previous Volume 342:1206-1207 April 20, 2000 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Because colorectal cancers usually arise from adenomatous polyps, it is believed that preventing the growth of adenomas in the colon and rectum or removing any that appear will prevent colorectal cancer.¹ Many have therefore awaited the results of the two important trials published in this issue of the Journal — a study of wheat-bran fiber by Alberts et al.² and the Polyp Prevention Trial.³ Both trials are well conceived, well designed, well implemented, and clearly presented. What is disappointing, however, is that the findings of both trials are negative. Three to four years of either taking a daily wheat-bran supplement . . . [Full Text of this Article]

References

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• Lanza, E., Yu, B., Murphy, G., Albert, P. S., Caan, B., Marshall, J. R., Lance, P., Paskett, E. D., Weissfeld, J., Slattery, M., Burt, R., Iber, F., Shike, M., Kikendall, J. W., Brewer, B. K., Schatzkin, A., the Polyp Prevention Trial Study Group, (2007). The Polyp Prevention Trial Continued Follow-up Study: No Effect of a Low-Fat, High-Fiber, High-Fruit, and -Vegetable Diet on Adenoma Recurrence Eight Years after Randomization. Cancer Epidemiol. Biomarkers Prev. 16: 1745-1752 [Abstract] [Full Text]  
• Wakai, K., Date, C., Fukui, M., Tamakoshi, K., Watanabe, Y., Hayakawa, N., Kojima, M., Kawado, M., Suzuki, K., Hashimoto, S., Tokudome, S., Ozasa, K., Suzuki, S., Toyoshima, H., Ito, Y., Tamakoshi, A., for the JACC Study Group, (2007). Dietary Fiber and Risk of Colorectal Cancer in the Japan Collaborative Cohort Study. Cancer Epidemiol. Biomarkers Prev. 16: 668-675 [Abstract] [Full Text]  
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• Erhardt, J. G, Meisner, C., Bode, J C., Bode, C. (2003). Lycopene, {beta}-carotene, and colorectal adenomas. Am. J. Clin. Nutr. 78: 1219-1224 [Abstract] [Full Text]  
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• Temple, N. J., Balay-Karperien, A. L. (2002). Nutrition in Cancer Prevention: An Integrated Approach. J. Am. Coll. Nutr. 21: 79-83 [Abstract] [Full Text]  
• Terry, P., Giovannucci, E., Michels, K. B., Bergkvist, L., Hansen, H., Holmberg, L., Wolk, A. (2001). Fruit, Vegetables, Dietary Fiber, and Risk of Colorectal Cancer. JNCI J Natl Cancer Inst 93: 525-533 [Abstract] [Full Text]  
• Whorton, J. (2000). Civilisation and the colon: constipation as the "disease of diseases". BMJ 321: 1586-1589 [Full Text]  
• Ornish, D., Davis, B. M., Gerber, M., Lowenfels, A., Maisonneuve, P., Muller, R. J., Duprey, P. A., Schatzkin, A., Lanza, E., Freedman, L., Alberts, D. S., Martinez, M. E., Marshall, J. R. (2000). High-Fiber Diet and Colorectal Adenomas. NEJM 343: 736-738 [Full Text]  
• (2000). Increasing Dietary Fiber Does Not Prevent Recurrent Colon Polyps. JWatch Women's Health 2000: 11-11 [Full Text]