FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 342:1255-1265 April 27, 2000 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Letters Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Myelofibrosis with myeloid metaplasia is classified broadly as a chronic myeloid disorder and, more specifically, as a chronic myeloproliferative disease¹ (Figure 1). The primary pathogenetic mechanism is a clonal stem-cell disorder that leads to ineffective erythropoiesis, dysplastic-megakaryocyte hyperplasia, and an increase in the ratio of immature granulocytes to total granulocytes. This clonal myeloproliferation is characteristically accompanied by reactive myelofibrosis (bone marrow fibrosis) and by extramedullary hematopoiesis in the spleen or in multiple organs. The diagnosis is often suspected when teardrop-shaped red cells and myeloid precursors are detected in the peripheral blood. The typical clinical features include marked splenomegaly, . . . [Full Text of this Article]

Terminology and Classification

Pathogenetic Mechanisms

Diagnosis

Differential Diagnosis

Clinical Features

Epidemiology

Clinical Presentation

Complications

Prognosis

Management

Drug Therapy

Splenectomy

Splenic Irradiation

Allogeneic Stem-Cell Transplantation

Autologous Stem-Cell Transplantation

Antifibrotic and Antiangiogenic Therapy

Conclusions

Source Information

From the Division of Hematology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn.

Address reprint requests to Dr. Tefferi at the Mayo Clinic, 200 First St. SW, Rochester, MN 55905, or at tefferi.ayalew@mayo.edu.

References

Related Letters:

A Patient with Myeloid Metaplasia of the Skin and Mouth
Jazieh A. R., Kyasa M. J.
Extract | Full Text  
N Engl J Med 2000; 343:1270-1271, Oct 26, 2000. Correspondence

Myelofibrosis with Myeloid Metaplasia
Guardiola P., Anderson J. E., Gluckman E., Benbassat J., Tefferi A., Nagorney D. M.
Extract | Full Text  
N Engl J Med 2000; 343:659-660, Aug 31, 2000. Correspondence

This article has been cited by other articles:

• Verstovsek, S. (2009). New Therapeutic Options for Myelofibrosis. Am Soc Clin Oncol Ed Book 2009: 426-429 [Abstract] [Full Text]  
• Zhou, L., Nguyen, A. N., Sohal, D., Ying Ma, J., Pahanish, P., Gundabolu, K., Hayman, J., Chubak, A., Mo, Y., Bhagat, T. D., Das, B., Kapoun, A. M., Navas, T. A., Parmar, S., Kambhampati, S., Pellagatti, A., Braunchweig, I., Zhang, Y., Wickrema, A., Medicherla, S., Boultwood, J., Platanias, L. C., Higgins, L. S., List, A. F., Bitzer, M., Verma, A. (2008). Inhibition of the TGF-{beta} receptor I kinase promotes hematopoiesis in MDS. Blood 112: 3434-3443 [Abstract] [Full Text]  
• Lataillade, J.-J., Pierre-Louis, O., Hasselbalch, H. C., Uzan, G., Jasmin, C., Martyre, M.-C., Le Bousse-Kerdiles, M.-C., on behalf of the French INSERM and the European EU, (2008). Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence. Blood 112: 3026-3035 [Abstract] [Full Text]  
• Patriarca, F., Bacigalupo, A., Sperotto, A., Isola, M., Soldano, F., Bruno, B., van Lint, M. T., Iori, A. P., Santarone, S., Porretto, F., Pioltelli, P., Visani, G., Iacopino, P., Fanin, R., Bosi, A., on behalf of the GITMO, (2008). Allogeneic hematopoietic stem cell transplantation in myelofibrosis: the 20-year experience of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). haematol 93: 1514-1522 [Abstract] [Full Text]  
• Passamonti, F., Rumi, E., Caramella, M., Elena, C., Arcaini, L., Boveri, E., Del Curto, C., Pietra, D., Vanelli, L., Bernasconi, P., Pascutto, C., Cazzola, M., Morra, E., Lazzarino, M. (2008). A dynamic prognostic model to predict survival in post-polycythemia vera myelofibrosis. Blood 111: 3383-3387 [Abstract] [Full Text]  
• Vener, C., Fracchiolla, N. S., Gianelli, U., Calori, R., Radaelli, F., Iurlo, A., Caberlon, S., Gerli, G., Boiocchi, L., Deliliers, G. L. (2008). Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis. Blood 111: 1862-1865 [Abstract] [Full Text]  
• Rambaldi, A., Barbui, T., Barosi, G. (2008). From Palliation to Epigenetic Therapy in Myelofibrosis. ASH Education Book 2008: 83-91 [Abstract] [Full Text]  
• Rumi, E., Passamonti, F., Della Porta, M. G., Elena, C., Arcaini, L., Vanelli, L., Del Curto, C., Pietra, D., Boveri, E., Pascutto, C., Cazzola, M., Lazzarino, M. (2007). Familial Chronic Myeloproliferative Disorders: Clinical Phenotype and Evidence of Disease Anticipation. JCO 25: 5630-5635 [Abstract] [Full Text]  
• Cairo, M. S. (2007). Myelofibrosis with myeloid metaplasia: targeted therapy. Blood 110: 2-3 [Full Text]  
• Wagner-Ballon, O., Pisani, D. F., Gastinne, T., Tulliez, M., Chaligne, R., Lacout, C., Aurade, F., Villeval, J.-L., Gonin, P., Vainchenker, W., Giraudier, S. (2007). Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice. Blood 110: 345-353 [Abstract] [Full Text]  
• Nakayama, T., Mutsuga, N., Tosato, G. (2007). FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood 109: 1363-1372 [Abstract] [Full Text]  
• Nakayama, T., Mutsuga, N., Tosato, G. (2007). Effect of Fibroblast Growth Factor 2 on Stromal Cell-Derived Factor 1 Production by Bone Marrow Stromal Cells and Hematopoiesis. JNCI J Natl Cancer Inst 99: 223-235 [Abstract] [Full Text]  
• Steensma, D. P., Richard, R. E. (2007). Myeloproliferative disorders. ASH-SAP 2007: 172-227 [Full Text]  
• Guglielmelli, P., Zini, R., Bogani, C., Salati, S., Pancrazzi, A., Bianchi, E., Mannelli, F., Ferrari, S., Le Bousse-Kerdiles, M.-C., Bosi, A., Barosi, G., Migliaccio, A. R., Manfredini, R., Vannucchi, A. M. (2007). Molecular Profiling of CD34+ Cells in Idiopathic Myelofibrosis Identifies a Set of Disease-Associated Genes and Reveals the Clinical Significance of Wilms' Tumor Gene 1 (WT1). Stem Cells 25: 165-173 [Abstract] [Full Text]  
• Campbell, P. J., Green, A. R. (2006). The Myeloproliferative Disorders. NEJM 355: 2452-2466 [Full Text]  
• Alvarez, R. H., Kantarjian, H. M., Cortes, J. E. (2006). Biology of Platelet-Derived Growth Factor and Its Involvement in Disease. Mayo Clin Proc. 81: 1241-1257 [Abstract] [Full Text]  
• Arana-Yi, C., Quintas-Cardama, A., Giles, F., Thomas, D., Carrasco-Yalan, A., Cortes, J., Kantarjian, H., Verstovsek, S. (2006). Advances in the Therapy of Chronic Idiopathic Myelofibrosis. The Oncologist 11: 929-943 [Abstract] [Full Text]  
• Tefferi, A., Cortes, J., Verstovsek, S., Mesa, R. A., Thomas, D., Lasho, T. L., Hogan, W. J., Litzow, M. R., Allred, J. B., Jones, D., Byrne, C., Zeldis, J. B., Ketterling, R. P., McClure, R. F., Giles, F., Kantarjian, H. M. (2006). Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood 108: 1158-1164 [Abstract] [Full Text]  
• Wagner-Ballon, O., Chagraoui, H., Prina, E., Tulliez, M., Milon, G., Raslova, H., Villeval, J.-L., Vainchenker, W., Giraudier, S. (2006). Monocyte/Macrophage Dysfunctions Do Not Impair the Promotion of Myelofibrosis by High Levels of Thrombopoietin.. J. Immunol. 176: 6425-6433 [Abstract] [Full Text]  
• Bock, O., Busche, G., Koop, C., Schroter, S., Buhr, T., Kreipe, H. (2006). Detection of the Single Hotspot Mutation in the JH2 Pseudokinase Domain of Janus Kinase 2 in Bone Marrow Trephine Biopsies Derived from Chronic Myeloproliferative Disorders. J. Mol. Diagn. 8: 170-177 [Abstract] [Full Text]  
• Wang, J., Darvishian, F. (2006). Extramedullary Hematopoiesis in Breast after Neoadjuvant Chemotherapy for Breast Carcinoma. Annals of Clinical & Laboratory Science 36: 475-478 [Abstract] [Full Text]  
• Martelli, F., Ghinassi, B., Panetta, B., Alfani, E., Gatta, V., Pancrazzi, A., Bogani, C., Vannucchi, A. M., Paoletti, F., Migliaccio, G., Migliaccio, A. R. (2005). Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds. Blood 106: 4102-4113 [Abstract] [Full Text]  
• Chim, C.-S., Kwong, Y.-L., Lie, A. K.-W., Ma, S.-K., Chan, C.-C., Wong, L.-G., San Kho, B. C., Lee, H.-K., Sim, J. P.-Y., Chan, C.-H., Chan, J. C.-W., Yeung, Y.-M., Law, M., Liang, R. (2005). Long-term Outcome of 231 Patients With Essential Thrombocythemia: Prognostic Factors for Thrombosis, Bleeding, Myelofibrosis, and Leukemia. Arch Intern Med 165: 2651-2658 [Abstract] [Full Text]  
• Tefferi, A. (2005). Pathogenesis of Myelofibrosis With Myeloid Metaplasia. JCO 23: 8520-8530 [Abstract] [Full Text]  
• Barosi, G., Bordessoule, D., Briere, J., Cervantes, F., Demory, J.-L., Dupriez, B., Gisslinger, H., Griesshammer, M., Hasselbalch, H., Kusec, R., Le Bousse-Kerdiles, M.-C., Liberato, N. L., Marchetti, M., Reilly, J. T., Thiele, J. (2005). Response criteria for myelofibrosis with myeloid metaplasia: results of an initiative of the European Myelofibrosis Network (EUMNET). Blood 106: 2849-2853 [Abstract] [Full Text]  
• Popat, U., Frost, A., Liu, E., May, R., Bag, R., Reddy, V., Prchal, J. T. (2005). New Onset of Myelofibrosis in Association with Pulmonary Arterial Hypertension. ANN INTERN MED 143: 466-467 [Full Text]  
• Sahasrabudhe, N, Davenport, A (2005). Myeloid metaplasia in the gall bladder: a case report. J. Clin. Pathol. 58: 998-999 [Abstract] [Full Text]  
• Tefferi, A., Barbui, T. (2005). bcr/abl-Negative, Classic Myeloproliferative Disorders: Diagnosis and Treatment. Mayo Clin Proc. 80: 1220-1232 [Abstract]  
• Massa, M., Rosti, V., Ramajoli, I., Campanelli, R., Pecci, A., Viarengo, G., Meli, V., Marchetti, M., Hoffman, R., Barosi, G. (2005). Circulating CD34+, CD133+, and Vascular Endothelial Growth Factor Receptor 2-Positive Endothelial Progenitor Cells in Myelofibrosis With Myeloid Metaplasia. JCO 23: 5688-5695 [Abstract] [Full Text]  
• Xu, M., Bruno, E., Chao, J., Huang, S., Finazzi, G., Fruchtman, S. M., Popat, U., Prchal, J. T., Barosi, G., Hoffman, R., for the MPD Research Consortium, (2005). Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases. Blood 105: 4508-4515 [Abstract] [Full Text]  
• Rondelli, D., Barosi, G., Bacigalupo, A., Prchal, J. T., Popat, U., Alessandrino, E. P., Spivak, J. L., Smith, B. D., Klingemann, H. G., Fruchtman, S., Hoffman, R. (2005). Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myelofibrosis with myeloid metaplasia. Blood 105: 4115-4119 [Abstract] [Full Text]  
• Jones, L. C., Tefferi, A., Vuong, P. T., Desmond, J. C., Hofmann, W.-K., Koeffler, H. P. (2005). Detection of Aberrant Gene Expression in CD34+ Hematopoietic Stem Cells from Patients with Agnogenic Myeloid Metaplasia Using Oligonucleotide Microarrays. Stem Cells 23: 631-637 [Abstract] [Full Text]  
• Vannucchi, A. M., Bianchi, L., Paoletti, F., Pancrazzi, A., Torre, E., Nishikawa, M., Zingariello, M., Di Baldassarre, A., Rana, R. A., Lorenzini, R., Alfani, E., Migliaccio, G., Migliaccio, A. R. (2005). A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-{beta}1 in the development of myelofibrosis. Blood 105: 3493-3501 [Abstract] [Full Text]  
• Toki, T., Katsuoka, F., Kanezaki, R., Xu, G., Kurotaki, H., Sun, J., Kamio, T., Watanabe, S., Tandai, S., Terui, K., Yagihashi, S., Komatsu, N., Igarashi, K., Yamamoto, M., Ito, E. (2005). Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Blood 105: 3100-3108 [Abstract] [Full Text]  
• Xu, M., Bruno, E., Chao, J., Ni, H., Lindgren, V., Nunez, R., Mahmud, N., Finazzi, G., Fruchtman, S. M., Popat, U., Liu, E., Prchal, J. T., Rondelli, D., Barosi, G., Hoffman, R. (2005). The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis. Blood 105: 1699-1705 [Abstract] [Full Text]  
• Mesa, R. A., Li, C.-Y., Ketterling, R. P., Schroeder, G. S., Knudson, R. A., Tefferi, A. (2005). Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases. Blood 105: 973-977 [Abstract] [Full Text]  
• Emadi, S., Clay, D., Desterke, C., Guerton, B., Maquarre, E., Charpentier, A., Jasmin, C., Le Bousse-Kerdiles, M.-C., for the French INSERM Research Network on MMM, (2005). IL-8 and its CXCR1 and CXCR2 receptors participate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis. Blood 105: 464-473 [Abstract] [Full Text]  
• Centurione, L., Di Baldassarre, A., Zingariello, M., Bosco, D., Gatta, V., Rana, R. A., Langella, V., Di Virgilio, A., Vannucchi, A. M., Migliaccio, A. R. (2004). Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice. Blood 104: 3573-3580 [Abstract] [Full Text]  
• Pardanani, A., Tefferi, A. (2004). Imatinib targets other than bcr/abl and their clinical relevance in myeloid disorders. Blood 104: 1931-1939 [Abstract] [Full Text]  
• Silver, R. T. (2004). Myelofibrosis: Thalidomide Finds a New Disease. Mayo Clin Proc. 79: 857-858  
• Mesa, R. A., Elliott, M. A., Schroeder, G., Tefferi, A. (2004). Durable Responses to Thalidomide-Based Drug Therapy for Myelofibrosis With Myeloid Metaplasia. Mayo Clin Proc. 79: 883-889 [Abstract]  
• Tefferi, A., Deeg, H. J. (2004). Deciding on Transplantation for Myelofibrosis: Setting the Record Straight. Mayo Clin Proc. 79: 953-954  
• Tefferi, A., Nagorney, D. M. (2004). The Spleen in Myelofibrosis With Myeloid Metaplasia. Mayo Clin Proc. 79: 503-503  
• Suetterlin, R., Baschong, W., Laeng, R. H. (2004). Immunofluorescence and Confocal Laser Scanning Microscopy of Chronic Myeloproliferative Disorders on Archival Formaldehyde-fixed Bone Marrow. J. Histochem. Cytochem. 52: 347-354 [Abstract] [Full Text]  
• Menon, K.V. N., Shah, V., Kamath, P. S. (2004). The Budd-Chiari Syndrome. NEJM 350: 578-585 [Full Text]  
• Marchetti, M., Barosi, G., Balestri, F., Viarengo, G., Gentili, S., Barulli, S., Demory, J.-L., Ilariucci, F., Volpe, A., Bordessoule, D., Grossi, A., Le Bousse-Kerdiles, M. C., Caenazzo, A., Pecci, A., Falcone, A., Broccia, G., Bendotti, C., Bauduer, F., Buccisano, F., Dupriez, B. (2004). Low-Dose Thalidomide Ameliorates Cytopenias and Splenomegaly in Myelofibrosis With Myeloid Metaplasia: A Phase II Trial. JCO 22: 424-431 [Abstract] [Full Text]  
• Tefferi, A. (2004). The Message Is Not the Median!-Reply-I. Mayo Clin Proc. 79: 275-276  
• O'Brien, S., Tefferi, A., Valent, P. (2004). Chronic Myelogenous Leukemia and Myeloproliferative Disease. ASH Education Book 2004: 146-162 [Abstract] [Full Text]  
• Deeg, H. J., Gooley, T. A., Flowers, M. E. D., Sale, G. E., Slattery, J. T., Anasetti, C., Chauncey, T. R., Doney, K., Georges, G. E., Kiem, H.-P., Martin, P. J., Petersdorf, E. W., Radich, J., Sanders, J. E., Sandmaier, B. M., Warren, E. H., Witherspoon, R. P., Storb, R., Appelbaum, F. R. (2003). Allogeneic hematopoietic stem cell transplantation for myelofibrosis. Blood 102: 3912-3918 [Abstract] [Full Text]  
• Louis, I., Dulude, G., Corneau, S., Brochu, S., Boileau, C., Meunier, C., Cote, C., Labrecque, N., Perreault, C. (2003). Changes in the lymph node microenvironment induced by oncostatin M. Blood 102: 1397-1404 [Abstract] [Full Text]  
• Maziarz, R. T., Mesa, R. A., Tefferi, A. (2003). Allogeneic Stem Cell Transplantation for Chronic Myeloproliferative Disorders and Myelodysplastic Syndromes: The Question Is 'When?'. Mayo Clin Proc. 78: 941-943  
• Martyre, M.-C., Steunou, V., LeBousse-Kerdiles, M.-C., Wietzerbin, J., Vannucchi, A. M., Migliaccio, A. R. (2003). Lack of alteration in GATA-1 expression in CD34+ hematopoietic progenitors from patients with idiopathic myelofibrosis. Blood 101: 5087-5089 [Full Text]  
• Tefferi, A. (2003). The Forgotten Myeloproliferative Disorder: Myeloid Metaplasia. The Oncologist 8: 225-231 [Abstract] [Full Text]  
• Chagraoui, H., Tulliez, M., Smayra, T., Komura, E., Giraudier, S., Yun, T., Lassau, N., Vainchenker, W., Wendling, F. (2003). Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO. Blood 101: 2983-2989 [Abstract] [Full Text]  
• Mesa, R. A., Steensma, D. P., Pardanani, A., Li, C.-Y., Elliott, M., Kaufmann, S. H., Wiseman, G., Gray, L. A., Schroeder, G., Reeder, T., Zeldis, J. B., Tefferi, A. (2003). A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia. Blood 101: 2534-2541 [Abstract] [Full Text]  
• Tefferi, A. (2003). Polycythemia Vera: A Comprehensive Review and Clinical Recommendations. Mayo Clin Proc. 78: 174-194 [Abstract]  
• Giraudier, S., Chagraoui, H., Komura, E., Barnache, S., Blanchet, B., LeCouedic, J. P., Smith, D. F., Larbret, F., Taksin, A.-L., Moreau-Gachelin, F., Casadevall, N., Tulliez, M., Hulin, A., Debili, N., Vainchenker, W. (2002). Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors. Blood 100: 2932-2940 [Abstract] [Full Text]  
• Bock, O., Schlue, J., Lehmann, U., von Wasielewski, R., Langer, F., Kreipe, H. (2002). Megakaryocytes from chronic myeloproliferative disorders show enhanced nuclear bFGF expression. Blood 100: 2274-2275 [Full Text]  
• Vannucchi, A. M., Bianchi, L., Cellai, C., Paoletti, F., Rana, R. A., Lorenzini, R., Migliaccio, G., Migliaccio, A. R. (2002). Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1low mice). Blood 100: 1123-1132 [Abstract] [Full Text]  
• Steensma, D. P., Mesa, R. A., Li, C.-Y., Gray, L., Tefferi, A. (2002). Etanercept, a soluble tumor necrosis factor receptor, palliates constitutional symptoms in patients with myelofibrosis with myeloid metaplasia: results of a pilot study. Blood 99: 2252-2254 [Abstract] [Full Text]  
• Devine, S. M., Hoffman, R., Verma, A., Shah, R., Bradlow, B. A., Stock, W., Maynard, V., Jessop, E., Peace, D., Huml, M., Thomason, D., Chen, Y.-H., van Besien, K. (2002). Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. Blood 99: 2255-2258 [Abstract] [Full Text]  
• Dingli, D., Utz, J. P., Krowka, M. J., Oberg, A. L., Tefferi, A. (2001). Unexplained Pulmonary Hypertension in Chronic Myeloproliferative Disorders. Chest 120: 801-808 [Abstract] [Full Text]  
• Anderson, J. E., Tefferi, A., Craig, F., Holmberg, L., Chauncey, T., Appelbaum, F. R., Guardiola, P., Callander, N., Freytes, C., Gazitt, Y., Razvillas, B., Deeg, H. J. (2001). Myeloablation and autologous peripheral blood stem cell rescue results in hematologic and clinical responses in patients with myeloid metaplasia with myelofibrosis. Blood 98: 586-593 [Abstract] [Full Text]  
• Rameshwar, P., Joshi, D. D., Yadav, P., Qian, J., Gascon, P., Chang, V. T., Anjaria, D., Harrison, J. S., Song, X. (2001). Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis. Blood 97: 3025-3031 [Abstract] [Full Text]  
• Deeg, H. J., Appelbaum, F. R. (2001). Stem-Cell Transplantation for Myelofibrosis. NEJM 344: 775-776 [Full Text]  
• Tefferi, A., Elliott, M. A. (2000). Serious myeloproliferative reactions associated with the use of thalidomide in myelofibrosis with myeloid metaplasia. Blood 96: 4007-4007 [Full Text]  
• Mesa, R. A., Hanson, C. A., Rajkumar, S. V., Schroeder, G., Tefferi, A. (2000). Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia. Blood 96: 3374-3380 [Abstract] [Full Text]  
• Jazieh, A. R., Kyasa, M. J. (2000). A Patient with Myeloid Metaplasia of the Skin and Mouth. NEJM 343: 1270-1271 [Full Text]  
• Guardiola, P., Anderson, J. E., Gluckman, E., Benbassat, J., Tefferi, A., Nagorney, D. M. (2000). Myelofibrosis with Myeloid Metaplasia. NEJM 343: 659-660 [Full Text]  
• Tefferi, A., Mesa, R. A., Gray, L. A., Steensma, D. P., Camoriano, J. K., Elliott, M. A., Pardanani, A., Ansell, S. M., Call, T. G., Colon-Otero, G., Schroeder, G., Hanson, C. A., Dewald, G. W., Kaufmann, S. H. (2002). Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia. Blood 99: 3854-3856 [Abstract] [Full Text]