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Previous Volume 342:1282-1283 April 27, 2000 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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What accounts for the ability of cancer cells to proliferate in a manner that is out of control, whereas normal cells die after 40 to 60 cycles of replication? One mechanism that leads to the death of a normal cell is erosion of the structure that caps the ends of chromosomes — the telomere (from the Greek telos, meaning end, and meros, a component) — each time a cell divides. The clinical relevance of telomeres is that a cancer cell, unlike a normal cell, can repair eroded telomeres. The existence of this repair mechanism suggests a novel target for cancer . . . [Full Text of this Article]

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