FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 342:1334-1349 May 4, 2000 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

The acute respiratory distress syndrome is a common, devastating clinical syndrome of acute lung injury that affects both medical and surgical patients. Since the last review of this syndrome appeared in the Journal,¹ more uniform definitions have been devised and important advances have occurred in the understanding of the epidemiology, natural history, and pathogenesis of the disease, leading to the design and testing of new treatment strategies. This article provides an overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome and discusses advances in the areas of pathogenesis, resolution, and treatment.

Historical Perspective and Definitions

The first description of . . . [Full Text of this Article]

Clinical, Pathological, and Radiographic Features

Epidemiology

Incidence

Clinical Disorders and Risk Factors

Outcomes

Pathogenesis

Endothelial and Epithelial Injury

Neutrophil-Dependent Lung Injury

Other Proinflammatory Mechanisms

            Cytokines

            Ventilator-Induced Lung Injury

            Other Mechanisms of Injury

Fibrosing Alveolitis

Resolution

Treatment

Approach to Treatment

Mechanical Ventilation

Fluid and Hemodynamic Management

Surfactant Therapy

Inhaled Nitric Oxide and Other Vasodilators

Glucocorticoids and Other Antiinflammatory Agents

Acceleration of Resolution

Conclusions

Source Information

From the Cardiovascular Research Institute (L.B.W., M.A.M.) and the Departments of Medicine (L.B.W., M.A.M.) and Anesthesia (M.A.M.), University of California, San Francisco, San Francisco.

Address reprint requests to Dr. Matthay at CVRI, Box 0130, 505 Parnassus Ave., University of California, San Francisco, San Francisco, CA 94143-0130, or at mmatt@itsa.ucsf.edu.

References

Related Letters:

Acute Respiratory Distress Syndrome
Suresh R., Kupfer Y., Tessler S., Ware L. B., Matthay M. A.
Extract | Full Text  
N Engl J Med 2000; 343:660-661, Aug 31, 2000. Correspondence

This article has been cited by other articles:

• Wang, Z., Rui, T., Yang, M., Valiyeva, F., Kvietys, P. R. (2008). Alveolar Macrophages from Septic Mice Promote Polymorphonuclear Leukocyte Transendothelial Migration via an Endothelial Cell Src Kinase/NADPH Oxidase Pathway. J. Immunol. 181: 8735-8744 [Abstract] [Full Text]  
• Murray, L. A., Knight, D. A., McAlonan, L., Argentieri, R., Joshi, A., Shaheen, F., Cunningham, M., Alexopolou, L., Flavell, R. A., Sarisky, R. T., Hogaboam, C. M. (2008). Deleterious Role of TLR3 during Hyperoxia-induced Acute Lung Injury. Am. J. Respir. Crit. Care Med. 178: 1227-1237 [Abstract] [Full Text]  
• Fan, E., Wilcox, M. E., Brower, R. G., Stewart, T. E., Mehta, S., Lapinsky, S. E., Meade, M. O., Ferguson, N. D. (2008). Recruitment Maneuvers for Acute Lung Injury: A Systematic Review. Am. J. Respir. Crit. Care Med. 178: 1156-1163 [Abstract] [Full Text]  
• Dossett, L. A., Heffernan, D., Lightfoot, M., Collier, B., Diaz, J. J., Sawyer, R. G., May, A. K. (2008). Obesity and Pulmonary Complications in Critically Injured Adults. Chest 134: 974-980 [Abstract] [Full Text]  
• Desai, L. P., Chapman, K. E., Waters, C. M. (2008). Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L958-L965 [Abstract] [Full Text]  
• Molina-Molina, M., Xaubet, A., Li, X., Abdul-Hafez, A., Friderici, K., Jernigan, K., Fu, W., Ding, Q., Pereda, J., Serrano-Mollar, A., Casanova, A., Rodriguez-Becerra, E., Morell, F., Ancochea, J., Picado, C., Uhal, B. D. (2008). Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression. Eur Respir J 32: 1004-1008 [Abstract] [Full Text]  
• Bucki, R., Byfield, F. J., Kulakowska, A., McCormick, M. E., Drozdowski, W., Namiot, Z., Hartung, T., Janmey, P. A. (2008). Extracellular Gelsolin Binds Lipoteichoic Acid and Modulates Cellular Response to Proinflammatory Bacterial Wall Components. J. Immunol. 181: 4936-4944 [Abstract] [Full Text]  
• Wurfel, M. M., Gordon, A. C., Holden, T. D., Radella, F., Strout, J., Kajikawa, O., Ruzinski, J. T., Rona, G., Black, R. A., Stratton, S., Jarvik, G. P., Hajjar, A. M., Nickerson, D. A., Rieder, M., Sevransky, J., Maloney, J. P., Moss, M., Martin, G., Shanholtz, C., Garcia, J. G. N., Gao, L., Brower, R., Barnes, K. C., Walley, K. R., Russell, J. A., Martin, T. R. (2008). Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis. Am. J. Respir. Crit. Care Med. 178: 710-720 [Abstract] [Full Text]  
• Chang, D. W., Hayashi, S., Gharib, S. A., Vaisar, T., King, S. T., Tsuchiya, M., Ruzinski, J. T., Park, D. R., Matute-Bello, G., Wurfel, M. M., Bumgarner, R., Heinecke, J. W., Martin, T. R. (2008). Proteomic and Computational Analysis of Bronchoalveolar Proteins during the Course of the Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 178: 701-709 [Abstract] [Full Text]  
• Eckle, T., Fullbier, L., Grenz, A., Eltzschig, H. K. (2008). Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L718-L724 [Abstract] [Full Text]  
• Liu, K. D., Levitt, J., Zhuo, H., Kallet, R. H., Brady, S., Steingrub, J., Tidswell, M., Siegel, M. D., Soto, G., Peterson, M. W., Chesnutt, M. S., Phillips, C., Weinacker, A., Thompson, B. T., Eisner, M. D., Matthay, M. A. (2008). Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury. Am. J. Respir. Crit. Care Med. 178: 618-623 [Abstract] [Full Text]  
• Hong, S.-B., Huang, Y., Moreno-Vinasco, L., Sammani, S., Moitra, J., Barnard, J. W., Ma, S.-F., Mirzapoiazova, T., Evenoski, C., Reeves, R. R., Chiang, E. T., Lang, G. D., Husain, A. N., Dudek, S. M., Jacobson, J. R., Ye, S. Q., Lussier, Y. A., Garcia, J. G. N. (2008). Essential Role of Pre-B-Cell Colony Enhancing Factor in Ventilator-induced Lung Injury. Am. J. Respir. Crit. Care Med. 178: 605-617 [Abstract] [Full Text]  
• Zuo, Y. Y., Tadayyon, S. M., Keating, E., Zhao, L., Veldhuizen, R. A. W., Petersen, N. O., Amrein, M. W., Possmayer, F. (2008). Atomic Force Microscopy Studies of Functional and Dysfunctional Pulmonary Surfactant Films, II: Albumin-Inhibited Pulmonary Surfactant Films and the Effect of SP-A. Biophys. J 95: 2779-2791 [Abstract] [Full Text]  
• Sevransky, J. E., Martin, G. S., Mendez-Tellez, P., Shanholtz, C., Brower, R., Pronovost, P. J., Needham, D. M. (2008). Pulmonary vs Nonpulmonary Sepsis and Mortality in Acute Lung Injury. Chest 134: 534-538 [Abstract] [Full Text]  
• Muralimohan, G., Rossi, R. J., Guernsey, L. A., Thrall, R. S., Vella, A. T. (2008). Inhalation of Staphylococcus aureus Enterotoxin A Induces IFN-{gamma} and CD8 T Cell-Dependent Airway and Interstitial Lung Pathology in Mice. J. Immunol. 181: 3698-3705 [Abstract] [Full Text]  
• Matute-Bello, G., Frevert, C. W., Martin, T. R. (2008). Animal models of acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L379-L399 [Abstract] [Full Text]  
• Zhang, H., Tasaka, S., Shiraishi, Y., Fukunaga, K., Yamada, W., Seki, H., Ogawa, Y., Miyamoto, K., Nakano, Y., Hasegawa, N., Miyasho, T., Maruyama, I., Ishizaka, A. (2008). Role of Soluble Receptor for Advanced Glycation End Products on Endotoxin-induced Lung Injury. Am. J. Respir. Crit. Care Med. 178: 356-362 [Abstract] [Full Text]  
• Shofer, S., Badea, C., Qi, Y., Potts, E., Foster, W. M., Johnson, G. A. (2008). A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. J. Appl. Physiol. 105: 669-677 [Abstract] [Full Text]  
• Ramchandran, R., Mehta, D., Vogel, S. M., Mirza, M. K., Kouklis, P., Malik, A. B. (2008). Critical role of Cdc42 in mediating endothelial barrier protection in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 295: L363-L369 [Abstract] [Full Text]  
• Brown, R. H., Irvin, C. G., Allen, G. B. III, Shapiro, S. D., Martin, W. J., Kolb, M. R. J., Hyde, D. M., Nieman, G. F., Cody, D. D., Ishii, M., Kadlecek, S. J., Driehuys, B., Rizi, R. R., Wu, A. M., Weber, W. A., Stout, D. B., on behalf of the ATS Small Animal Imaging Subcommi, (2008). An Official ATS Conference Proceedings: Advances in Small-Animal Imaging Application to Lung Pathophysiology. Proc Am Thorac Soc 5: 591-600 [Full Text]  
• Burnham, E. L., Halkar, R., Burks, M., Moss, M. (2008). The Effects of Alcohol Abuse on Pulmonary Alveolar-Capillary Barrier Function in Humans. Alcohol Alcohol 0: agn051v1-agn051 [Abstract] [Full Text]  
• Sio, S. W. S., Puthia, M. K., Lu, J., Moochhala, S., Bhatia, M. (2008). The Neuropeptide Substance P Is a Critical Mediator of Burn-Induced Acute Lung Injury. J. Immunol. 180: 8333-8341 [Abstract] [Full Text]  
• Swee, M., Wilson, C. L., Wang, Y., McGuire, J. K., Parks, W. C. (2008). Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients. J. Leukoc. Biol. 83: 1404-1412 [Abstract] [Full Text]  
• Kambas, K., Markiewski, M. M., Pneumatikos, I. A., Rafail, S. S., Theodorou, V., Konstantonis, D., Kourtzelis, I., Doumas, M. N., Magotti, P., DeAngelis, R. A., Lambris, J. D., Ritis, K. D. (2008). C5a and TNF-{alpha} Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome. J. Immunol. 180: 7368-7375 [Abstract] [Full Text]  
• Nagata, N., Iwata, N., Hasegawa, H., Fukushi, S., Harashima, A., Sato, Y., Saijo, M., Taguchi, F., Morikawa, S., Sata, T. (2008). Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice. Am. J. Pathol. 172: 1625-1637 [Abstract] [Full Text]  
• Su, X., Johansen, M., Looney, M. R., Brown, E. J., Matthay, M. A. (2008). CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia. J. Immunol. 180: 6947-6953 [Abstract] [Full Text]  
• Zhou, G., Dada, L. A., Sznajder, J. I. (2008). Regulation of alveolar epithelial function by hypoxia. Eur Respir J 31: 1107-1113 [Abstract] [Full Text]  
• Saito, F., Tasaka, S., Inoue, K.-i., Miyamoto, K., Nakano, Y., Ogawa, Y., Yamada, W., Shiraishi, Y., Hasegawa, N., Fujishima, S., Takano, H., Ishizaka, A. (2008). Role of Interleukin-6 in Bleomycin-Induced Lung Inflammatory Changes in Mice. Am. J. Respir. Cell Mol. Bio. 38: 566-571 [Abstract] [Full Text]  
• Bastarache, J. A., Wang, L., Wang, Z., Albertine, K. H., Matthay, M. A., Ware, L. B. (2008). Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L874-L881 [Abstract] [Full Text]  
• Boueiz, A., Damarla, M., Hassoun, P. M. (2008). Xanthine oxidoreductase in respiratory and cardiovascular disorders. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L830-L840 [Abstract] [Full Text]  
• Yasuda, H., Leelahavanichkul, A., Tsunoda, S., Dear, J. W., Takahashi, Y., Ito, S., Hu, X., Zhou, H., Doi, K., Childs, R., Klinman, D. M., Yuen, P. S. T., Star, R. A. (2008). Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am. J. Physiol. Renal Physiol. 294: F1050-F1058 [Abstract] [Full Text]  
• Matthay, M. A. (2008). Treatment of Acute Lung Injury: Clinical and Experimental Studies. Proc Am Thorac Soc 5: 297-299 [Abstract] [Full Text]  
• Kamp, R., Sun, X., Garcia, J. G. N. (2008). Making Genomics Functional: Deciphering the Genetics of Acute Lung Injury. Proc Am Thorac Soc 5: 348-353 [Abstract] [Full Text]  
• Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. K. B., Dockrell, D. H. (2008). Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia. Am. J. Respir. Crit. Care Med. 177: 887-895 [Abstract] [Full Text]  
• Ganter, M. T., Roux, J., Miyazawa, B., Howard, M., Frank, J. A., Su, G., Sheppard, D., Violette, S. M., Weinreb, P. H., Horan, G. S., Matthay, M. A., Pittet, J.-F. (2008). Interleukin-1{beta} Causes Acute Lung Injury via {alpha}v{beta}5 and {alpha}v{beta}6 Integrin-Dependent Mechanisms. Circ. Res. 102: 804-812 [Abstract] [Full Text]  
• Solodushko, V., Parker, J. C., Fouty, B. (2008). Pulmonary Microvascular Endothelial Cells Form a Tighter Monolayer when Grown in Chronic Hypoxia. Am. J. Respir. Cell Mol. Bio. 38: 491-497 [Abstract] [Full Text]  
• Morse, D., Choi, A. M. K. (2008). Inhaled CO in the treatment of acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L642-L643 [Full Text]  
• Matthay, M. A, Lee, J. (2008). {beta}2 Adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax 63: 189-190 [Full Text]  
• Liu, K. D., Matthay, M. A. (2008). Advances in Critical Care for the Nephrologist: Acute Lung Injury/ARDS. CJASN 3: 578-586 [Abstract] [Full Text]  
• Koyner, J. L., Murray, P. T. (2008). Mechanical Ventilation and Lung-Kidney Interactions. CJASN 3: 562-570 [Full Text]  
• Tiruppathi, C., Shimizu, J., Miyawaki-Shimizu, K., Vogel, S. M., Bair, A. M., Minshall, R. D., Predescu, D., Malik, A. B. (2008). Role of NF-{kappa}B-dependent Caveolin-1 Expression in the Mechanism of Increased Endothelial Permeability Induced by Lipopolysaccharide. J. Biol. Chem. 283: 4210-4218 [Abstract] [Full Text]  
• Gattinoni, L., Caironi, P. (2008). Refining Ventilatory Treatment for Acute Lung Injury and Acute Respiratory Distress Syndrome. JAMA 299: 691-693 [Full Text]  
• Lyons, W. S., Calfee, C. S., Matthay, M. A. (2008). Nonventilatory Treatments for ARDS?: Future Directions. Chest 133: 586-587 [Full Text]  
• Quesnel, C., Marchand-Adam, S., Fabre, A., Marchal-Somme, J., Philip, I., Lasocki, S., Lecon, V., Crestani, B., Dehoux, M. (2008). Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L334-L343 [Abstract] [Full Text]  
• Sivaramakrishnan, S., DeGiulio, J. V., Lorand, L., Goldman, R. D., Ridge, K. M. (2008). Micromechanical properties of keratin intermediate filament networks. Proc. Natl. Acad. Sci. USA 105: 889-894 [Abstract] [Full Text]  
• Bream-Rouwenhorst, H. R., Beltz, E. A., Ross, M. B., Moores, K. G. (2008). Recent developments in the management of acute respiratory distress syndrome in adults. Am J Health Syst Pharm 65: 29-36 [Abstract] [Full Text]  
• Tidswell, M. (2008). Nonventilatory Interventions in ALI/ARDS: Recent Work. J Intensive Care Med 23: 70-72  
• Laing, S. J., Jackson, A. R., Walters, R., Lloyd-Jones, E., Whitham, M., Maassen, N., Walsh, N. P. (2008). Human blood neutrophil responses to prolonged exercise with and without a thermal clamp. J. Appl. Physiol. 104: 20-26 [Abstract] [Full Text]  
• Elizur, A., Adair-Kirk, T. L., Kelley, D. G., Griffin, G. L., deMello, D. E., Senior, R. M. (2008). Tumor Necrosis Factor-{alpha} from Macrophages Enhances LPS-Induced Clara Cell Expression of Keratinocyte-Derived Chemokine. Am. J. Respir. Cell Mol. Bio. 38: 8-15 [Abstract] [Full Text]  
• Chen, J., Lecuona, E., Briva, A., Welch, L. C., Sznajder, J. I. (2008). Carbonic Anhydrase II and Alveolar Fluid Reabsorption during Hypercapnia. Am. J. Respir. Cell Mol. Bio. 38: 32-37 [Abstract] [Full Text]  
• White, K. E., Ding, Q., Moore, B. B., Peters-Golden, M., Ware, L. B., Matthay, M. A., Olman, M. A. (2008). Prostaglandin E2 Mediates IL-1 -Related Fibroblast Mitogenic Effects in Acute Lung Injury through Differential Utilization of Prostanoid Receptors. J. Immunol. 180: 637-646 [Abstract] [Full Text]  
• Papaiahgari, S., Yerrapureddy, A., Reddy, S. R., Reddy, N. M., Dodd-O, J. M., Crow, M. T., Grigoryev, D. N., Barnes, K., Tuder, R. M., Yamamoto, M., Kensler, T. W., Biswal, S., Mitzner, W., Hassoun, P. M., Reddy, S. P. (2007). Genetic and Pharmacologic Evidence Links Oxidative Stress to Ventilator-induced Lung Injury in Mice. Am. J. Respir. Crit. Care Med. 176: 1222-1235 [Abstract] [Full Text]  
• Haworth, O., Levy, B. D. (2007). Endogenous lipid mediators in the resolution of airway inflammation. Eur Respir J 30: 980-992 [Abstract] [Full Text]  
• Yalcin, H. C., Perry, S. F., Ghadiali, S. N. (2007). Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening. J. Appl. Physiol. 103: 1796-1807 [Abstract] [Full Text]  
• Thammanomai, A., Majumdar, A., Bartolak-Suki, E., Suki, B. (2007). Effects of reduced tidal volume ventilation on pulmonary function in mice before and after acute lung injury. J. Appl. Physiol. 103: 1551-1559 [Abstract] [Full Text]  
• Krupa, A., Walencka, M. J., Shrivastava, V., Loyd, T., Fudala, R., Frevert, C. W., Martin, T. R., Kurdowska, A. K. (2007). Anti-KC Autoantibody:KC Complexes Cause Severe Lung Inflammation in Mice via IgG Receptors. Am. J. Respir. Cell Mol. Bio. 37: 532-543 [Abstract] [Full Text]  
• Talmor, D., Sarge, T., Legedza, A., O'Donnell, C. R., Ritz, R., Loring, S. H., Malhotra, A. (2007). Cytokine Release Following Recruitment Maneuvers. Chest 132: 1434-1439 [Abstract] [Full Text]  
• Tephly, L. A., Carter, A. B. (2007). Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L1143-L1155 [Abstract] [Full Text]  
• Wu, R., Dong, W., Zhou, M., Zhang, F., Marini, C. P., Ravikumar, T. S., Wang, P. (2007). Ghrelin Attenuates Sepsis-induced Acute Lung Injury and Mortality in Rats. Am. J. Respir. Crit. Care Med. 176: 805-813 [Abstract] [Full Text]  
• Xu, H., Ferro, T. J., Chu, S. (2007). Cigarette smoke condensate inhibits ENaC {alpha}-subunit expression in lung epithelial cells. Eur Respir J 30: 633-642 [Abstract] [Full Text]  
• Collard, H. R., Moore, B. B., Flaherty, K. R., Brown, K. K., Kaner, R. J., King, T. E. Jr., Lasky, J. A., Loyd, J. E., Noth, I., Olman, M. A., Raghu, G., Roman, J., Ryu, J. H., Zisman, D. A., Hunninghake, G. W., Colby, T. V., Egan, J. J., Hansell, D. M., Johkoh, T., Kaminski, N., Kim, D. S., Kondoh, Y., Lynch, D. A., Muller-Quernheim, J., Myers, J. L., Nicholson, A. G., Selman, M., Toews, G. B., Wells, A. U., Martinez, F. J., the Idiopathic Pulmonary Fibrosis Clinical Researc, (2007). Acute Exacerbations of Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 176: 636-643 [Abstract] [Full Text]  
• Hamanaka, K., Jian, M.-Y., Weber, D. S., Alvarez, D. F., Townsley, M. I., Al-Mehdi, A. B., King, J. A., Liedtke, W., Parker, J. C. (2007). TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L923-L932 [Abstract] [Full Text]  
• Wygrecka, M., Markart, P., Fink, L., Guenther, A., Preissner, K. T (2007). Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS). Thorax 62: 880-888 [Abstract] [Full Text]  
• Mutlu, G. M., Machado-Aranda, D., Norton, J. E., Bellmeyer, A., Urich, D., Zhou, R., Dean, D. A. (2007). Electroporation-mediated Gene Transfer of the Na+,K+-ATPase Rescues Endotoxin-induced Lung Injury. Am. J. Respir. Crit. Care Med. 176: 582-590 [Abstract] [Full Text]  
• Sato, H., Griffith, G. W., Hall, C. M., Toomasian, J. M., Hirschl, R. B., Bartlett, R. H., Cook, K. E. (2007). Seven-Day Artificial Lung Testing in an In-Parallel Configuration. Ann. Thorac. Surg. 84: 988-994 [Abstract] [Full Text]  
• Sadegh Soltan-Sharifi, M., Mojtahedzadeh, M., Najafi, A., Reza Khajavi, M., Reza Rouini, M., Moradi, M., Mohammadirad, A., Abdollahi, M. (2007). Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms. Hum Exp Toxicol 26: 697-703 [Abstract]  
• Cepkova, M., Kapur, V., Ren, X., Quinn, T., Zhuo, H., Foster, E., Liu, K. D., Matthay, M. A. (2007). Pulmonary Dead Space Fraction and Pulmonary Artery Systolic Pressure as Early Predictors of Clinical Outcome in Acute Lung Injury. Chest 132: 836-842 [Abstract] [Full Text]  
• Desai, L. P., Sinclair, S. E., Chapman, K. E., Hassid, A., Waters, C. M. (2007). High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L769-L778 [Abstract] [Full Text]  
• Thomas, Z., Fraser, G. L (2007). An Update on the Diagnosis of Adrenal Insufficiency and the Use of Corticotherapy in Critical Illness. The Annals of Pharmacotherapy 41: 1456-1465 [Abstract] [Full Text]  
• Prows, D. R., Hafertepen, A. P., Winterberg, A. V., Gibbons, W. J. Jr., Liu, C., Nick, T. G. (2007). Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Physiol. Genomics 30: 271-281 [Abstract] [Full Text]  
• Lee, J. W., Fang, X., Dolganov, G., Fremont, R. D., Bastarache, J. A., Ware, L. B., Matthay, M. A. (2007). Acute Lung Injury Edema Fluid Decreases Net Fluid Transport across Human Alveolar Epithelial Type II Cells. J. Biol. Chem. 282: 24109-24119 [Abstract] [Full Text]  
• Rice, T. W., Wheeler, A. P., Bernard, G. R., Hayden, D. L., Schoenfeld, D. A., Ware, L. B., for the National Institutes of Health, National He, (2007). Comparison of the SpO2/FIO2 Ratio and the PaO2/FIO2 Ratio in Patients With Acute Lung Injury or ARDS. Chest 132: 410-417 [Abstract] [Full Text]  
• Gupta, N., Su, X., Popov, B., Lee, J. W., Serikov, V., Matthay, M. A. (2007). Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice. J. Immunol. 179: 1855-1863 [Abstract] [Full Text]  
• Nonas, S. A., Vinasco, L. M., Ma, S. F., Jacobson, J. R., Desai, A. A., Dudek, S. M., Flores, C., Hassoun, P. M., Sam, L., Ye, S. Q., Moitra, J., Barnard, J., Grigoryev, D. N., Lussier, Y. A., Garcia, J. G. N. (2007). Use of consomic rats for genomic insights into ventilator-associated lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L292-L302 [Abstract] [Full Text]  
• Fang, W.-F., Cho, J. H., He, Q., Lin, M.-C., Wu, C.-C., Voelkel, N. F., Douglas, I. S. (2007). Lipid A fraction of LPS induces a discrete MAPK activation in acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L336-L344 [Abstract] [Full Text]  
• Reutershan, J., Cagnina, R. E., Chang, D., Linden, J., Ley, K. (2007). Therapeutic Anti-Inflammatory Effects of Myeloid Cell Adenosine Receptor A2a Stimulation in Lipopolysaccharide-Induced Lung Injury. J. Immunol. 179: 1254-1263 [Abstract] [Full Text]  
• Frank, J. A., Briot, R., Lee, J. W., Ishizaka, A., Uchida, T., Matthay, M. A. (2007). Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L52-L59 [Abstract] [Full Text]  
• Wilson, M. R., Goddard, M. E., O'Dea, K. P., Choudhury, S., Takata, M. (2007). Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L60-L68 [Abstract] [Full Text]  
• Dada, L. A., Novoa, E., Lecuona, E., Sun, H., Sznajder, J. I. (2007). Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells. J. Cell Sci. 120: 2214-2222 [Abstract] [Full Text]  
• Bastarache, J. A, Wang, L., Geiser, T., Wang, Z., Albertine, K. H, Matthay, M. A, Ware, L. B (2007). The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax 62: 608-616 [Abstract] [Full Text]  
• Vyas-Read, S., Shaul, P. W., Yuhanna, I. S., Willis, B. C. (2007). Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L212-L221 [Abstract] [Full Text]  
• Eckle, T., Fullbier, L., Wehrmann, M., Khoury, J., Mittelbronn, M., Ibla, J., Rosenberger, P., Eltzschig, H. K. (2007). Identification of Ectonucleotidases CD39 and CD73 in Innate Protection during Acute Lung Injury. J. Immunol. 178: 8127-8137 [Abstract] [Full Text]  
• Petty, J. M., Sueblinvong, V., Lenox, C. C., Jones, C. C., Cosgrove, G. P., Cool, C. D., Rai, P. R., Brown, K. K., Weiss, D. J., Poynter, M. E., Suratt, B. T. (2007). Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury. J. Immunol. 178: 8148-8157 [Abstract] [Full Text]  
• Fremont, R. D., Kallet, R. H., Matthay, M. A., Ware, L. B. (2007). Postobstructive Pulmonary Edema: A Case for Hydrostatic Mechanisms. Chest 131: 1742-1746 [Abstract] [Full Text]  
• Jerng, J.-S., Hsu, Y.-C., Wu, H.-D., Pan, H.-Z., Wang, H.-C., Shun, C.-T., Yu, C.-J., Yang, P.-C. (2007). Role of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model. Thorax 62: 527-535 [Abstract] [Full Text]  
• Allen, G. B., Leclair, T., Cloutier, M., Thompson-Figueroa, J., Bates, J. H. T. (2007). The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspiration. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L1580-L1589 [Abstract] [Full Text]  
• Cheng, D.-s., Han, W., Chen, S. M., Sherrill, T. P., Chont, M., Park, G.-Y., Sheller, J. R., Polosukhin, V. V., Christman, J. W., Yull, F. E., Blackwell, T. S. (2007). Airway Epithelium Controls Lung Inflammation and Injury through the NF-{kappa}B Pathway. J. Immunol. 178: 6504-6513 [Abstract] [Full Text]  
• Alvira, C. M., Abate, A., Yang, G., Dennery, P. A., Rabinovitch, M. (2007). Nuclear Factor-{kappa}B Activation in Neonatal Mouse Lung Protects against Lipopolysaccharide-induced Inflammation. Am. J. Respir. Crit. Care Med. 175: 805-815 [Abstract] [Full Text]  
• Adhikari, N. K J, Burns, K. E A, Friedrich, J. O, Granton, J. T, Cook, D. J, Meade, M. O (2007). Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 334: 779-779 [Abstract] [Full Text]  
• Karmpaliotis, D., Kirtane, A. J., Ruisi, C. P., Polonsky, T., Malhotra, A., Talmor, D., Kosmidou, I., Jarolim, P., de Lemos, J. A., Sabatine, M. S., Gibson, C. M., Morrow, D. (2007). Diagnostic and Prognostic Utility of Brain Natriuretic Peptide in Subjects Admitted to the ICU With Hypoxic Respiratory Failure Due to Noncardiogenic and Cardiogenic Pulmonary Edema. Chest 131: 964-971 [Abstract] [Full Text]  
• Wang, L., Bastarache, J. A., Wickersham, N., Fang, X., Matthay, M. A., Ware, L. B. (2007). Novel Role of the Human Alveolar Epithelium in Regulating Intra-Alveolar Coagulation. Am. J. Respir. Cell Mol. Bio. 36: 497-503 [Abstract] [Full Text]  
• Glynos, C., Kotanidou, A., Orfanos, S. E., Zhou, Z., Simoes, D. C. M., Magkou, C., Roussos, C., Papapetropoulos, A. (2007). Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292: R1448-R1455 [Abstract] [Full Text]  
• Su, G., Hodnett, M., Wu, N., Atakilit, A., Kosinski, C., Godzich, M., Huang, X. Z., Kim, J. K., Frank, J. A., Matthay, M. A., Sheppard, D., Pittet, J.-F. (2007). Integrin {alpha}vbeta5 Regulates Lung Vascular Permeability and Pulmonary Endothelial Barrier Function. Am. J. Respir. Cell Mol. Bio. 36: 377-386 [Abstract] [Full Text]  
• Solodushko, V., Fouty, B. (2007). Proproliferative phenotype of pulmonary microvascular endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L671-L677 [Abstract] [Full Text]  
• Morris, A. E., Stapleton, R. D., Rubenfeld, G. D., Hudson, L. D., Caldwell, E., Steinberg, K. P. (2007). The Association Between Body Mass Index and Clinical Outcomes in Acute Lung Injury. Chest 131: 342-348 [Abstract] [Full Text]  
• Bonnans, C., Levy, B. D. (2007). Lipid Mediators as Agonists for the Resolution of Acute Lung Inflammation and Injury. Am. J. Respir. Cell Mol. Bio. 36: 201-205 [Abstract] [Full Text]  
• Jin, S.-W., Zhang, L., Lian, Q.-Q., Liu, D., Wu, P., Yao, S.-L., Ye, D.-Y. (2007). Posttreatment with Aspirin-Triggered Lipoxin A4 Analog Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice: The Role of Heme Oxygenase-1. Anesth. Analg. 104: 369-377 [Abstract] [Full Text]  
• Terragni, P. P., Rosboch, G., Tealdi, A., Corno, E., Menaldo, E., Davini, O., Gandini, G., Herrmann, P., Mascia, L., Quintel, M., Slutsky, A. S., Gattinoni, L., Ranieri, V. M. (2007). Tidal Hyperinflation during Low Tidal Volume Ventilation in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 175: 160-166 [Abstract] [Full Text]  
• Meyer, N. J., Garcia, J. G. N. (2007). Wading into the Genomic Pool to Unravel Acute Lung Injury Genetics. Proc Am Thorac Soc 4: 69-76 [Abstract] [Full Text]  
• Harris, R. S., Schuster, D. P. (2007). Visualizing lung function with positron emission tomography. J. Appl. Physiol. 102: 448-458 [Abstract] [Full Text]