The acute respiratory distress syndrome is a common, devastatingclinical syndrome of acute lung injury that affects both medicaland surgical patients. Since the last review of this syndromeappeared in the Journal,1 more uniform definitions have beendevised and important advances have occurred in the understandingof the epidemiology, natural history, and pathogenesis of thedisease, leading to the design and testing of new treatmentstrategies. This article provides an overview of the definitions,clinical features, and epidemiology of the acute respiratorydistress syndrome and discusses advances in the areas of pathogenesis,resolution, and treatment.
From the Cardiovascular Research Institute (L.B.W., M.A.M.) and the Departments of Medicine (L.B.W., M.A.M.) and Anesthesia (M.A.M.), University of California, San Francisco, San Francisco.
Address reprint requests to Dr. Matthay at CVRI, Box 0130, 505 Parnassus Ave., University of California, San Francisco, San Francisco, CA 94143-0130, or at mmatt@itsa.ucsf.edu.
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