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Previous Volume 342:1334-1349 May 4, 2000 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The acute respiratory distress syndrome is a common, devastating clinical syndrome of acute lung injury that affects both medical and surgical patients. Since the last review of this syndrome appeared in the Journal,¹ more uniform definitions have been devised and important advances have occurred in the understanding of the epidemiology, natural history, and pathogenesis of the disease, leading to the design and testing of new treatment strategies. This article provides an overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome and discusses advances in the areas of pathogenesis, resolution, and treatment.

Historical Perspective and Definitions

The first description of . . . [Full Text of this Article]

Clinical, Pathological, and Radiographic Features

Epidemiology

Incidence

Clinical Disorders and Risk Factors

Outcomes

Pathogenesis

Endothelial and Epithelial Injury

Neutrophil-Dependent Lung Injury

Other Proinflammatory Mechanisms

            Cytokines

            Ventilator-Induced Lung Injury

            Other Mechanisms of Injury

Fibrosing Alveolitis

Resolution

Treatment

Approach to Treatment

Mechanical Ventilation

Fluid and Hemodynamic Management

Surfactant Therapy

Inhaled Nitric Oxide and Other Vasodilators

Glucocorticoids and Other Antiinflammatory Agents

Acceleration of Resolution

Conclusions

Source Information

From the Cardiovascular Research Institute (L.B.W., M.A.M.) and the Departments of Medicine (L.B.W., M.A.M.) and Anesthesia (M.A.M.), University of California, San Francisco, San Francisco.

Address reprint requests to Dr. Matthay at CVRI, Box 0130, 505 Parnassus Ave., University of California, San Francisco, San Francisco, CA 94143-0130, or at mmatt@itsa.ucsf.edu.

References

Related Letters:

Acute Respiratory Distress Syndrome
Suresh R., Kupfer Y., Tessler S., Ware L. B., Matthay M. A.
Extract | Full Text  
N Engl J Med 2000; 343:660-661, Aug 31, 2000. Correspondence

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