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Correspondence
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Volume 342:1450 May 11, 2000 Number 19
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Transient Enhanced Uptake of 123I-Metaiodobenzylguanidine in the Contralateral Adrenal Region after Resection of an Adrenal Pheochromocytoma

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To the Editor: Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of patients may have recurrences, and follow-up is therefore essential.1 The tests used for this purpose include measurements of 24-hour urinary catecholamine secretion and the clonidine suppression test. A specific method for detecting chromaffin in tumors is 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy.2 In vitro experiments suggest that MIBG accumulates in adrenergic tissue by means of the norepinephrine-uptake transporter.3 We describe a patient with a pheochromocytoma in whom 123I-MIBG . . . [Full Text of this Article]

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