The major determinants of survival after witnessed out-of-hospitalcardiac arrest due to ventricular fibrillation include whethera bystander initiates cardiopulmonary resuscitation (CPR) andhow quickly defibrillation is accomplished.
The now-classic observations of Eisenberg et al. were that amongpatients with out-of-hospital cardiac arrest due to ventricularfibrillation, 43 percent survived to leave the hospital if CPRwas initiated by a bystander within four minutes and if definitivetherapy was delivered within eight minutes.1 Survival decreasedto less than 7 percent if basic CPR was not initiated until8 minutes, and no patient survived after 16 minutes of untreatedventricular fibrillation.1
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