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Previous Volume 342:1611-1612 May 25, 2000 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: X-linked agammaglobulinemia is characterized by a profound defect in the production of antibodies of all isotypes; the defect is related to impaired B-lymphocyte differentiation resulting from mutations in the gene for B tyrosine kinase.¹ Immunity against viral infections is generally intact in patients with X-linked agammaglobulinemia, with the exception of an unusual susceptibility to enteroviral infection.¹ Chronic intestinal inflammation mimicking Crohn's disease has been described in a few patients with X-linked agammaglobulinemia.^2,3 Its origin, however, is unknown.

A 22-year-old man with X-linked agammaglobulinemia that had been diagnosed at the age of 9 was referred for chronic abdominal . . . [Full Text of this Article]

References

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• Bayry, J., Lacroix-Desmazes, S., Donkova-Petrini, V., Carbonneil, C., Misra, N., Lepelletier, Y., Delignat, S., Varambally, S., Oksenhendler, E., Levy, Y., Debre, M., Kazatchkine, M. D., Hermine, O., Kaveri, S. V. (2004). Natural antibodies sustain differentiation and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 101: 14210-14215 [Abstract] [Full Text]