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Previous Volume 342:1664-1666 June 1, 2000 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Crohn's disease is an idiopathic, immunologically mediated disorder in which medically or surgically induced remissions are followed by relapses. The goals of treatment are to induce and then maintain remission through the long-term use of nontoxic agents.¹ Several medications that are effective in the short term do not result in sustained remission, and conversely, agents used for maintenance may have minimal effects on active disease. For example, prednisone usually suppresses active inflammation, but long-term use is associated with high rates of relapse and unacceptable toxicity. The most effective drugs for maintenance therapy — mercaptopurine and azathioprine — have limited immediate . . . [Full Text of this Article]

References

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• Schultz, M., Munro, K., Tannock, G. W., Melchner, I., Gottl, C., Schwietz, H., Scholmerich, J., Rath, H. C. (2004). Effects of Feeding a Probiotic Preparation (SIM) Containing Inulin on the Severity of Colitis and on the Composition of the Intestinal Microflora in HLA-B27 Transgenic Rats. CVI 11: 581-587 [Abstract] [Full Text]  
• Silberstein, L. E., Toy, P. (2001). Research Opportunities in Transfusion Medicine. JAMA 285: 577-580 [Abstract] [Full Text]