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Previous Volume 342:1871-1876 June 22, 2000 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Acromegaly is a systemic disorder caused by sustained hypersecretion of growth hormone. The typical features include thickening of the skin, enlargement of the hands, feet, and mandible, and visceromegaly.^1,2 Active disease is indicated by the presence of excessive sweating and soft-tissue swelling.^1,2 Most patients with acromegaly have a growth hormone–secreting pituitary adenoma,³ but a few (less than 1 percent) have hypothalamic or other tumors that secrete growth hormone–releasing hormone.⁴ Isolated ectopic secretion of growth hormone has been reported only once, in a patient with a pancreatic islet-cell tumor.^5,6 Here we describe a patient with recurrent non-Hodgkin's lymphoma and acromegaly caused . . . [Full Text of this Article]

Case Report

Methods

Assays

Tissue and Cell Studies

Reverse-Transcriptase Polymerase Chain Reaction

Immunofluorescence Microscopy

Cell-Culture Experiments

Results

Expression of mRNA in Lymphoma Tissue

Immunofluorescence Microscopy

In Vitro Secretion of Growth Hormone

Discussion

Source Information

From the Department of Medicine II, Klinikum der Albert-Ludwigs-Universität Freiburg, Freiburg (F.B., V.S., D.M., H.E.B., M.R.); the Medical Department, Klinikum Innenstadt der Ludwig-Maximilians-Universität, Munich (C.J.S., M.B.); and the German Cancer Research Center, Heidelberg (P.L.) — all in Germany.

Address reprint requests to Dr. Reincke at Abteilung Innere Medizin II, Klinikum der Albert-Ludwigs-Universität Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany, or at reincke@med1.ukl.uni-freiburg.de.

References

This article has been cited by other articles:

• Melmed, S. (2006). Acromegaly. NEJM 355: 2558-2573 [Full Text]  
• Nylen, E. S., Muller, B. (2004). Endocrine Changes in Critical Illness. J Intensive Care Med 19: 67-82 [Abstract]