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Previous Volume 342:1960-1968 June 29, 2000 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Colorectal cancer is the second leading cause of cancer-related deaths in the United States. It is estimated that this cancer will develop in 130,000 people in the United States in 2000 and that 56,000 will die from the disease.¹ Surgical resection remains the only curative treatment, and the likelihood of cure is greater when the disease is detected at an earlier pathological stage. Early detection is the goal of screening programs that use periodic examination of stool for occult blood, with or without intermittent endoscopic examination of the bowel. Three randomized studies have shown a reduction in mortality of 15 . . . [Full Text of this Article]

Chemopreventive Agents

Aspirin and Other Nonsteroidal Antiinflammatory Drugs

            Mechanisms

            Familial Adenomatous Polyposis

            Clinical Studies

Folate

Calcium

Hormone-Replacement Therapy

Vitamins, Antioxidants, and Fiber

Conclusions

Source Information

From the Department of Adult Oncology, Dana–Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.

Address reprint requests to Dr. Mayer at the Dana–Farber Cancer Institute, 44 Binney St., Boston, MA 02115.

References

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