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Previous Volume 342:1969-1978 June 29, 2000 Number 26 Next

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Pulmonary Langerhans'-cell histiocytosis forms part of a spectrum of diseases characterized by monoclonal proliferation and infiltration of organs by Langerhans' cells (Table 1).¹ Several organ systems may be involved in Langerhans'-cell histiocytosis, including the lungs, bone, skin, pituitary gland, liver, lymph nodes, and thyroid.² Lung involvement may occur either in isolation or as part of a multiorgan disease (Table 1). The term "pulmonary Langerhans'-cell histiocytosis" is used to refer to disease in adults that affects the lung, either in isolation or in addition to other organ systems.

View this table: [in this window] [in a new window]   Table 1. Simplified System of Classification of Langerhans'-Cell Histiocytosis in Adults.

 
. . . [Full Text of this Article]

Epidemiologic and Demographic Characteristics

Langerhans' Cells

Pathogenesis

Histopathological Features

Clinical Features

Pulmonary-Function Testing

Chest Radiography

High-Resolution Computed Tomography

Bronchoalveolar Lavage and Lung Biopsy

Approach to Diagnosis

Treatment

Prognosis

Source Information

From the Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine (R.V., J.H.R., A.H.L.), the Department of Biochemistry and Molecular Biology (A.H.L.), and the Department of Diagnostic Radiology (T.H.), Mayo Clinic Foundation, Rochester, Minn.; and the Division of Anatomic Pathology, Mayo Clinic, Scottsdale, Ariz. (T.V.C.).

Address reprint requests to Dr. Limper at the Thoracic Diseases Research Unit, 601C Guggenheim Bldg., Mayo Clinic and Foundation, Rochester, MN 55905, or at limper.andrew@mayo.edu.

References

Related Letters:

Pulmonary Langerhans'-Cell Histiocytosis
Brown R. E., Arico M., Nichols K. E., Danesino C., O'Regan A. W., Brophy M. T., Miller W. T., Vassallo R., Ryu J. H., Limper A. H.
Extract | Full Text  
N Engl J Med 2000; 343:1654-1656, Nov 30, 2000. Correspondence

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