Over the past 20 to 30 years, major advances have been madein the diagnosis and treatment of congenital heart disease inchildren. As a result, many children with such disease now surviveto adulthood. In the United States alone, the population ofadults with congenital heart disease, either surgically correctedor uncorrected, is estimated to be increasing at a rate of about5 percent per year; this year there will be almost 1 millionsuch patients.1 This two-part review discusses the more commonacyanotic and cyanotic congenital heart conditions that physicianswho care for adults are likely to encounter.
From the Department of Internal Medicine, Cardiovascular Division, University of Texas Southwestern Medical Center, Dallas.
Address reprint requests to Dr. Hillis at Rm. CS7.102, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9047.
References
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Schwerzmann, M., Windecker, S., Meier, B.
(2008). Swiss Cheese-Like Atrial Septal Defect. Circulation
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MANGHAT, N E, RACHAPALLI, V, LINGEN, R V., VEITCH, A M, ROOBOTTOM, C A, MORGAN-HUGHES, G J
(2008). Imaging the heart valves using ECG-gated 64-detector row cardiac CT. Br. J. Radiol.
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[Abstract][Full Text]
BENTHAM, J., BHATTACHARYA, S.
(2008). Genetic Mechanisms Controlling Cardiovascular Development. Ann. N. Y. Acad. Sci.
1123: 10-19
[Abstract][Full Text]
ElBardissi, A. W., Dearani, J. A., Suri, R. M., Danielson, G. K.
(2008). Left-Sided Partial Anomalous Pulmonary Venous Connections. Ann. Thorac. Surg.
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[Abstract][Full Text]
Padalino, M. A., Speggiorin, S., Rizzoli, G., Crupi, G., Vida, V. L., Bernabei, M., Gargiulo, G., Giamberti, A., Santoro, F., Vosa, C., Pacileo, G., Calabro, R., Daliento, L., Stellin, G.
(2007). Midterm results of surgical intervention for congenital heart disease in adults: An Italian multicenter study. J. Thorac. Cardiovasc. Surg.
134: 106-113
[Abstract][Full Text]
Pierpont, M. E., Basson, C. T., Benson, D. W. Jr, Gelb, B. D., Giglia, T. M., Goldmuntz, E., McGee, G., Sable, C. A., Srivastava, D., Webb, C. L.
(2007). Genetic Basis for Congenital Heart Defects: Current Knowledge: A Scientific Statement From the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: Endorsed by the American Academy of Pediatrics. Circulation
115: 3015-3038
[Abstract][Full Text]
Ford, P. F., Farber, M. A.
(2007). Role of Endovascular Therapies in the Management of Diverse Thoracic Aortic Pathology. PERSPECT VASC SURG ENDOVASC THER
19: 134-143
[Abstract]
Leschka, S., Oechslin, E., Husmann, L., Desbiolles, L., Marincek, B., Genoni, M., Pretre, R., Jenni, R., Wildermuth, S., Alkadhi, H.
(2007). Pre- and Postoperative Evaluation of Congenital Heart Disease in Children and Adults with 64-Section CT. RadioGraphics
27: 829-846
[Abstract][Full Text]
Diller, G.-P., Gatzoulis, M. A.
(2007). Pulmonary Vascular Disease in Adults With Congenital Heart Disease. Circulation
115: 1039-1050
[Abstract][Full Text]
McClain, C. D., McGowan, F. X., Kovatsis, P. G.
(2006). Laparoscopic Surgery in a Patient with Fontan Physiology. Anesth. Analg.
103: 856-858
[Abstract][Full Text]
Diller, G.-P., Dimopoulos, K., Okonko, D., Uebing, A., Broberg, C. S., Babu-Narayan, S., Bayne, S., Poole-Wilson, P. A., Sutton, R., Francis, D. P., Gatzoulis, M. A.
(2006). Heart Rate Response During Exercise Predicts Survival in Adults With Congenital Heart Disease. J Am Coll Cardiol
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[Abstract][Full Text]
Post, M. C., Budts, W.
(2006). The Relationship Between Migraine and Right-to-Left Shunt: Fact or Fiction?. Chest
130: 896-901
[Abstract][Full Text]
Shih, M.-C. P., Tholpady, A., Kramer, C. M., Sydnor, M. K., Hagspiel, K. D.
(2006). Surgical and endovascular repair of aortic coarctation: normal findings and appearance of complications on CT angiography and MR angiography.. Am. J. Roentgenol.
187: W302-W312
[Abstract][Full Text]
Moffett, B S, Parham, A L, Caudilla, C D, Mott, A R, Gurwitch, K D
(2006). Oral anticoagulation in a pediatric hospital: impact of a quality improvement initiative on warfarin management strategies.. Qual Saf Health Care
15: 240-243
[Abstract][Full Text]
Malnick, S. D.H., Shimoni, S., Zimhony, O.
(2006). An unusual case of endocarditis.. CMAJ
174: 1087-1088
[Full Text]
Diller, G.-P., Okonko, D., Uebing, A., Ho, S. Y., Gatzoulis, M. A.
(2006). Cardiac resynchronization therapy for adult congenital heart disease patients with a systemic right ventricle: analysis of feasibility and review of early experience.. Europace
8: 267-272
[Abstract][Full Text]
Russell, I. A., Rouine-Rapp, K., Stratmann, G., Miller-Hance, W. C.
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(2006). Report of the National Heart, Lung, and Blood Institute Working Group on Research in Adult Congenital Heart Disease. J Am Coll Cardiol
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[Abstract][Full Text]
Vida, V. L., Barnoya, J., O'Connell, M., Leon-Wyss, J., Larrazabal, L. A., Castaneda, A. R.
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47: 326-331
[Abstract][Full Text]
Al-Bustami, O., Sharifi, M., Hijazi, Z. M., Burks, J. T., Bacha, E. A.
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56: 647-650
[Abstract]
Leon-Wyss, J., Vida, V. L., Veras, O., Vides, I., Gaitan, G., O'Connell, M., Castaneda, A. R.
(2005). Modified Extrapleural Ligation of Patent Ductus Arteriosus: A Convenient Surgical Approach in a Developing Country. Ann. Thorac. Surg.
79: 632-635
[Abstract][Full Text]
Biancaniello, T.
(2005). Innocent Murmurs. Circulation
111: e20-e22
[Full Text]
Lovell, A. T.
(2004). Anaesthetic implications of grown-up congenital heart disease. Br J Anaesth
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[Abstract][Full Text]
Tonder, N., Kober, L., Hassager, C.
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5: 228-230
[Abstract][Full Text]
Mott, A. R., Feltes, T. F., McKenzie, E. D., Andropoulos, D. B., Bezold, L. I., Fenrich, A. L., Bedford, S. L., El-Said, H., Stayer, S. A., Fraser, C. D. Jr
(2004). Improved early results with the Fontan operation in adults with functional single ventricle. Ann. Thorac. Surg.
77: 1334-1340
[Abstract][Full Text]
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(2003). ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American college of cardiology/American heart association task force on practice guidelines (ACC/AHA/ASE committee to update the 1997 guidelines for the clinical application of echocardiography). J Am Coll Cardiol
42: 954-970
[Full Text]
Cheitlin, M. D., Armstrong, W. F., Aurigemma, G. P., Beller, G. A., Bierman, F. Z., Davis, J. L., Douglas, P. S., Faxon, D. P., Gillam, L. D., Kimball, T. R., Kussmaul, W. G., Pearlman, A. S., Philbrick, J. T., Rakowski, H., Thys, D. M., Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Gregoratos, G., Anderson, J. L., Hiratzka, L. F., Faxon, D. P., Ann Hunt, S., Fuster, V., Jacobs, A. K., Gibbons, R. J., Russell, R. O.
(2003). ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of Echocardiography: Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). Circulation
108: 1146-1162
[Full Text]
Bolger, A. P, Coats, A. J.S, Gatzoulis, M. A
(2003). Congenital heart disease: the original heart failure syndrome. Eur Heart J
24: 970-976
[Abstract][Full Text]
Gaba, R. C., Carlos, R. C., Weadock, W. J., Reddy, G. P., Sneider, M. B., Cascade, P. N.
(2002). Cardiovascular MR Imaging: Technique Optimization and Detection of Disease in Clinical Practice. RadioGraphics
22: e6-e6
[Abstract][Full Text]
Bolger, A. P., Sharma, R., Li, W., Leenarts, M., Kalra, P. R., Kemp, M., Coats, A. J.S., Anker, S. D., Gatzoulis, M. A.
(2002). Neurohormonal Activation and the Chronic Heart Failure Syndrome in Adults With Congenital Heart Disease. Circulation
106: 92-99
[Abstract][Full Text]
SANDOVAL, J., AGUIRRE, J. S., PULIDO, T., MARTINEZ-GUERRA, M. L., SANTOS, E., ALVARADO, P., ROSAS, M., BAUTISTA, E.
(2001). Nocturnal Oxygen Therapy in Patients with the Eisenmenger Syndrome. Am. J. Respir. Crit. Care Med.
164: 1682-1687
[Abstract][Full Text]