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Volume 342:289-290 January 27, 2000 Number 4
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Dofetilide for Atrial Fibrillation

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 by Torp-Pedersen, C.
To the Editor: Contemporary pharmacotherapy for patients with advanced congestive heart failure (New York Heart Association functional class III or IV) typically involves the concomitant use of digoxin, loop diuretics, angiotensin-converting–enzyme inhibitors, and increasingly, beta-blockers. In the September 16 issue of the Journal, Torp-Pedersen and coworkers1 reported that dofetilide had a neutral effect on the risk of death from any cause, reduced the risk of hospitalization for worsening congestive heart failure, and was effective in restoring (and maintaining) sinus rhythm in patients with atrial fibrillation. However, it is unclear whether therapy with digoxin was an exclusion criterion, according to the . . . [Full Text of this Article]

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