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Previous Volume 342:344-345 February 3, 2000 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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We tend to view type 1 diabetes mellitus as a chronic autoimmune disease with a preclinical phase that usually lasts for a number of years.¹ The classic symptoms of type 1 diabetes — hyperglycemia and ketosis — are thought to occur late in its course, only after 80 to 90 percent of the beta cells of the pancreatic islets have been destroyed. Data that provide strong support for this view have been obtained in numerous prospective studies of first-degree relatives of patients with type 1 diabetes; the relatives were followed because they had islet-cell antibodies.² The conventional view of autoimmune . . . [Full Text of this Article]

References

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• Sakaue, S., Nagata, M., Wakabayashi, O., Honda, T., Yoshimura, H., Yamaguchi, E., Nishimura, M. (2002). A Case of Fulminant Type 1 Diabetes With Elevated Rheumatoid Factor and the Temporal Presence of Thyroid-Stimulating Hormone Receptor Antibody. Diabetes Care 25: 935-936 [Full Text]