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Previous Volume 342:483-492 February 17, 2000 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Age-related macular degeneration, a deterioration of the central portion of the retina, is the chief cause of severe and irreversible loss of vision in developed countries.^1,2 There is no effective treatment for most patients with age-related macular degeneration, and many patients therefore resort to experimental treatments. Physicians must know how to counsel their patients about the limitations and risks of these experimental therapies. Fortunately, several clinical trials sponsored by both the National Eye Institute and the private sector are evaluating novel prophylactic and therapeutic interventions. In addition, there is much exciting, ongoing basic research, some of which may lead to . . . [Full Text of this Article]

Clinical Features and Classification

Epidemiology

Course and Visual Prognosis

Treatments Evaluated in Clinical Trials

Laser Photocoagulation Therapy

Photodynamic Therapy

Interferon Alfa-2a

Investigational Treatments

Submacular Surgery

External-Beam Radiation Therapy

Thalidomide

Treatments Not Yet Evaluated in Clinical Trials

Indocyanine Green–Guided Laser Treatment

Retinal Transplantation and Transplantation of Retinal Pigment Epithelium

Retinal Translocation

Retinal Prosthesis

Gene Therapy

Visual Rehabilitation and Counseling

Prophylaxis

Laser Treatment

Nutrition and Dietary Supplements

Conclusions

Source Information

From the Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania Health System (S.L.F., J.W.B., M.G.M.), and the Department of Ophthalmology, Wills Eye Hospital, Thomas Jefferson University (A.C.H.) — both in Philadelphia.

Address reprint requests to Dr. Fine at the Scheie Eye Institute, University of Pennsylvania Health System, 51 N. 39th St., Philadelphia, PA 19104-2689.

References

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• Nishihara, H., Kondo, M., Ishikawa, K., Sugita, T., Piao, C.-H., Nakamura, Y., Terasaki, H. (2008). Focal Macular Electroretinograms in Eyes with Wet-type Age-Related Macular Degeneration. IOVS 49: 3121-3125 [Abstract] [Full Text]  
• Iriyama, A., Fujiki, R., Inoue, Y., Takahashi, H., Tamaki, Y., Takezawa, S., Takeyama, K., Jang, W.-D., Kato, S., Yanagi, Y. (2008). A2E, a Pigment of the Lipofuscin of Retinal Pigment Epithelial Cells, Is an Endogenous Ligand for Retinoic Acid Receptor. J. Biol. Chem. 283: 11947-11953 [Abstract] [Full Text]  
• Bretillon, L., Acar, N., Seeliger, M. W., Santos, M., Maire, M. A., Juaneda, P., Martine, L., Gregoire, S., Joffre, C., Bron, A. M., Creuzot-Garcher, C. (2008). ApoB100,LDLR-/- Mice Exhibit Reduced Electroretinographic Response and Cholesteryl Esters Deposits in the Retina. IOVS 49: 1307-1314 [Abstract] [Full Text]  
• Kanda, A., Chen, W., Othman, M., Branham, K. E. H., Brooks, M., Khanna, R., He, S., Lyons, R., Abecasis, G. R., Swaroop, A. (2007). A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc. Natl. Acad. Sci. USA 104: 16227-16232 [Abstract] [Full Text]  
• Cheung, N., Shankar, A., Klein, R., Folsom, A. R., Couper, D. J., Wong, T. Y., for the Atherosclerosis Risk in Communities (ARIC), (2007). Age-Related Macular Degeneration and Cancer Mortality in the Atherosclerosis Risk in Communities Study. Arch Ophthalmol 125: 1241-1247 [Abstract] [Full Text]  
• Rovner, B. W., Casten, R. J., Hegel, M. T., Leiby, B. E., Tasman, W. S. (2007). Preventing Depression in Age-Related Macular Degeneration. Arch Gen Psychiatry 64: 886-892 [Abstract] [Full Text]  
• Sahel, J.-A., Bandello, F., Augustin, A., Maurel, F., Negrini, C., Berdeaux, G. H., for the MICMAC Study Group, (2007). Health-Related Quality of Life and Utility in Patients With Age-Related Macular Degeneration. Arch Ophthalmol 125: 945-951 [Abstract] [Full Text]  
• Kamei, M., Yoneda, K., Kume, N., Suzuki, M., Itabe, H., Matsuda, K.-i., Shimaoka, T., Minami, M., Yonehara, S., Kita, T., Kinoshita, S. (2007). Scavenger Receptors for Oxidized Lipoprotein in Age-Related Macular Degeneration. IOVS 48: 1801-1807 [Abstract] [Full Text]  
• Cheung, N., Liao, D., Amirul Islam, F M, Klein, R., Jin Wang, J., Yin Wong, T. (2007). Is early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Study. Br. J. Ophthalmol. 91: 430-433 [Abstract] [Full Text]  
• Wang, W., Connor, S. L, Johnson, E. J, Klein, M. L, Hughes, S., Connor, W. E (2007). Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. Am. J. Clin. Nutr. 85: 762-769 [Abstract] [Full Text]  
• Wahl, H.-W., Schilling, O., Becker, S. (2007). Age-Related Macular Degeneration and Change in Psychological Control: Role of Time Since Diagnosis and Functional Ability. J. Gerontol. B Psychol. Sci. Soc. Sci. 62: P90-P97 [Abstract] [Full Text]  
• Bandello, F., Lafuma, A., Berdeaux, G. (2007). Public Health Impact of Neovascular Age-Related Macular Degeneration Treatments Extrapolated from Visual Acuity. IOVS 48: 96-103 [Abstract] [Full Text]  
• de Jong, P. T.V.M. (2006). Age-Related Macular Degeneration. NEJM 355: 1474-1485 [Full Text]  
• Wong, T. Y., Klein, R., Sun, C., Mitchell, P., Couper, D. J., Lai, H., Hubbard, L. D., Sharrett, A. R., for the Atherosclerosis Risk in Communities Study, (2006). Age-Related Macular Degeneration and Risk for Stroke. ANN INTERN MED 145: 98-106 [Abstract] [Full Text]  
• Espinosa-Heidmann, D. G., Suner, I. J., Catanuto, P., Hernandez, E. P., Marin-Castano, M. E., Cousins, S. W. (2006). Cigarette Smoke-Related Oxidants and the Development of Sub-RPE Deposits in an Experimental Animal Model of Dry AMD. IOVS 47: 729-737 [Abstract] [Full Text]  
• Becker, S., Wahl, H.-W., Schilling, O., Burmedi, D. (2005). Assistive Device Use in Visually Impaired Older Adults: Role of Control Beliefs. Gerontologist 45: 739-746 [Abstract] [Full Text]  
• Ayyagari, R., Mandal, M. N. A., Karoukis, A. J., Chen, L., McLaren, N. C., Lichter, M., Wong, D. T., Hitchcock, P. F., Caruso, R. C., Moroi, S. E., Maumenee, I. H., Sieving, P. A. (2005). Late-Onset Macular Degeneration and Long Anterior Lens Zonules Result from a CTRP5 Gene Mutation. IOVS 46: 3363-3371 [Abstract] [Full Text]  
• Fisher, S. A., Abecasis, G. R., Yashar, B. M., Zareparsi, S., Swaroop, A., Iyengar, S. K., Klein, B. E.K., Klein, R., Lee, K. E., Majewski, J., Schultz, D. W., Klein, M. L., Seddon, J. M., Santangelo, S. L., Weeks, D. E., Conley, Y. P., Mah, T. S., Schmidt, S., Haines, J. L., Pericak-Vance, M. A., Gorin, M. B., Schulz, H. L., Pardi, F., Lewis, C. M., Weber, B. H.F. (2005). Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet 14: 2257-2264 [Abstract] [Full Text]  
• Matsuda, S., Gomi, F., Oshima, Y., Tohyama, M., Tano, Y. (2005). Vascular Endothelial Growth Factor Reduced and Connective Tissue Growth Factor Induced by Triamcinolone in ARPE19 Cells under Oxidative Stress. IOVS 46: 1062-1068 [Abstract] [Full Text]  
• Bora, P. S., Sohn, J.-H., Cruz, J. M. C., Jha, P., Nishihori, H., Wang, Y., Kaliappan, S., Kaplan, H. J., Bora, N. S. (2005). Role of Complement and Complement Membrane Attack Complex in Laser-Induced Choroidal Neovascularization. J. Immunol. 174: 491-497 [Abstract] [Full Text]  
• Birk, T., Hickl, S., Wahl, H.-W., Miller, D., Kammerer, A., Holz, F., Becker, S., Volcker, H. E. (2004). Development and Pilot Evaluation of a Psychosocial Intervention Program for Patients With Age-Related Macular Degeneration. Gerontologist 44: 836-843 [Abstract] [Full Text]  
• Smith, D H, Fenn, P, Drummond, M (2004). Cost effectiveness of photodynamic therapy with verteporfin for age related macular degeneration: the UK case. Br. J. Ophthalmol. 88: 1107-1112 [Abstract] [Full Text]  
• Cho, E., Seddon, J. M., Rosner, B., Willett, W. C., Hankinson, S. E. (2004). Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoids and Risk of Age-Related Maculopathy. Arch Ophthalmol 122: 883-892 [Abstract] [Full Text]  
• Mori, M., Metzger, D., Picaud, S., Hindelang, C., Simonutti, M., Sahel, J., Chambon, P., Mark, M. (2004). Retinal Dystrophy Resulting from Ablation of RXR{alpha} in the Mouse Retinal Pigment Epithelium. Am. J. Pathol. 164: 701-710 [Abstract] [Full Text]  
• Espinosa-Heidmann, D. G., Sall, J., Hernandez, E. P., Cousins, S. W. (2004). Basal Laminar Deposit Formation in APO B100 Transgenic Mice: Complex Interactions between Dietary Fat, Blue Light, and Vitamin E. IOVS 45: 260-266 [Abstract] [Full Text]  
• McGwin, G Jr, Owsley, C, Curcio, C A, Crain, R J (2003). The association between statin use and age related maculopathy. Br. J. Ophthalmol. 87: 1121-1125 [Abstract] [Full Text]  
• Wu, K H C, Madigan, M C, Billson, F A, Penfold, P L (2003). Differential expression of GFAP in early v late AMD: a quantitative analysis. Br. J. Ophthalmol. 87: 1159-1166 [Abstract] [Full Text]  
• Arden, G. B., Wolf, J. E. (2003). Differential Effects of Light and Alcohol on the Electro-oculographic Responses of Patients with Age-Related Macular Disease. IOVS 44: 3226-3232 [Abstract] [Full Text]  
• Kalayoglu, M. V., Galvan, C., Mahdi, O. S., Byrne, G. I., Mansour, S. (2003). Serological Association Between Chlamydia pneumoniae Infection and Age-Related Macular Degeneration. Arch Ophthalmol 121: 478-482 [Abstract] [Full Text]  
• Bora, P. S., Hu, Z., Tezel, T. H., Sohn, J.-H., Kang, S. G., Cruz, J. M. C., Bora, N. S., Garen, A., Kaplan, H. J. (2003). Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc. Natl. Acad. Sci. USA 100: 2679-2684 [Abstract] [Full Text]  
• Bok, D. (2002). New insights and new approaches toward the study of age-related macular degeneration. Proc. Natl. Acad. Sci. USA 99: 14619-14621 [Full Text]  
• Marmorstein, L. Y., Munier, F. L., Arsenijevic, Y., Schorderet, D. F., McLaughlin, P. J., Chung, D., Traboulsi, E., Marmorstein, A. D. (2002). Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. Proc. Natl. Acad. Sci. USA 99: 13067-13072 [Abstract] [Full Text]  
• Lau, J T F, Lee, V, Fan, D, Lau, M, Michon, J (2002). Knowledge about cataract, glaucoma, and age related macular degeneration in the Hong Kong Chinese population. Br. J. Ophthalmol. 86: 1080-1084 [Abstract] [Full Text]  
• Rovner, B. W., Casten, R. J., Tasman, W. S. (2002). Effect of Depression on Vision Function in Age-Related Macular Degeneration. Arch Ophthalmol 120: 1041-1044 [Abstract] [Full Text]  
• Rovner, B. W., Casten, R. J. (2002). Activity Loss and Depression in Age-Related Macular Degeneration. AJGP 10: 305-310 [Abstract] [Full Text]  
• Curran Celentano, J., Burke, J. D., Hammond, B. R. Jr. (2002). In Vivo Assessment of Retinal Carotenoids: Macular Pigment Detection Techniques and Their Impact on Monitoring Pigment Status. J. Nutr. 132: 535S-539 [Abstract] [Full Text]  
• Kanuga, N., Winton, H. L., Beauchene, L., Koman, A., Zerbib, A., Halford, S., Couraud, P.-O., Keegan, D., Coffey, P., Lund, R. D., Adamson, P., Greenwood, J. (2002). Characterization of Genetically Modified Human Retinal Pigment Epithelial Cells Developed for In Vitro and Transplantation Studies. IOVS 43: 546-555 [Abstract] [Full Text]  
• Age-Related Eye Disease Study Research Group, (2001). A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8. Arch Ophthalmol 119: 1417-1436 [Abstract] [Full Text]  
• Taylor, H. R, Keeffe, J. E (2001). World blindness: a 21st century perspective. Br. J. Ophthalmol. 85: 261-266 [Full Text]  
• Kutty, R. K., Kutty, G., Samuel, W., Duncan, T., Bridges, C. C., El-Sherbeeny, A., Nagineni, C. N., Smith, S. B., Wiggert, B. (2001). Molecular Characterization and Developmental Expression of NORPEG, a Novel Gene Induced by Retinoic Acid. J. Biol. Chem. 276: 2831-2840 [Abstract] [Full Text]