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Previous Volume 342:648-650 March 2, 2000 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Knowledge of Whipple's disease started with Whipple's report in 1907 of a medical missionary with an illness that had begun five years earlier with episodes of arthritis but that subsequently included weight loss, cough, fever, diarrhea, hypotension, abdominal swelling, increased skin pigmentation, and severe anemia.¹ Findings at autopsy consisted of polyserositis, aortic-valve lesions, and prominent deposition of fat within intestinal mucosa and mesenteric lymph nodes, with marked infiltration by foamy macrophages. The pattern of fat deposition suggested that this disorder was an obscure disease of fat metabolism, and Whipple proposed the name "intestinal lipodystrophy."

Whipple's description represents the ideal single . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Mancini, F., Sbaragli, S., Colivicchi, G., Cassone, A., Ciervo, A. (2009). Fourteen Years of Severe Arthralgia in a Man without Gastrointestinal Symptoms: Atypical Whipple's Disease. J. Clin. Microbiol. 47: 492-495 [Abstract] [Full Text]  
• Moos, V., Kunkel, D., Marth, T., Feurle, G. E., LaScola, B., Ignatius, R., Zeitz, M., Schneider, T. (2006). Reduced Peripheral and Mucosal Tropheryma whipplei-Specific Th1 Response in Patients with Whipple's Disease. J. Immunol. 177: 2015-2022 [Abstract] [Full Text]  
• Crapoulet, N., Barbry, P., Raoult, D., Renesto, P. (2006). Global Transcriptome Analysis of Tropheryma whipplei in Response to Temperature Stresses.. J. Bacteriol. 188: 5228-5239 [Abstract] [Full Text]  
• Ghigo, E., Capo, C., Aurouze, M., Tung, C.-H., Gorvel, J.-P., Raoult, D., Mege, J.-L. (2002). Survival of Tropheryma whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification. Infect. Immun. 70: 1501-1506 [Abstract] [Full Text]