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Previous Volume 343:64-66 July 6, 2000 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Francis, G. S. Related Article by The Heart Outcomes Prevention Evaluation Study Investigators PubMed Citation

To the Editor: The Heart Outcomes Prevention Evaluation Study investigators (Jan. 20 issue)¹ found that the administration of ramipril to a population of high-risk patients significantly reduced the rates of myocardial infarction, stroke, and death from cardiovascular causes. However, the data provided in this study raise questions as to whether angiotensin-converting–enzyme (ACE) inhibitors offer substantive clinical benefits over current therapeutic standards.

The authors state that "the benefits of ramipril were observed among patients who were already taking a number of effective treatments, such as aspirin, beta-blockers, and lipid-lowering agents, indicating that the inhibition of angiotensin-converting–enzyme offers an additional approach to . . . [Full Text of this Article]

References

This article has been cited by other articles:

• London, G. M., Asmar, R. G., O'Rourke, M. F., Safar, M. E., REASON Project Investigators, (2004). Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril/Indapamide in hypertensive subjects: comparison with atenolol. J Am Coll Cardiol 43: 92-99 [Abstract] [Full Text]  
• Nichols, W. W., Schuler, B., O'Rourke, M. F., Mathew, J., Sleight, P., Lonn, E., Yi, Q., Pogue, J., Bosch, J., Yusuf, S., Johnstone, D., Sussex, B., Probstfield, J. (2002). Ramipril and Cardiovascular Risk Reduction * Response. Circulation 105 : e194-e195 [Full Text]  
• Pauca, A. L., O'Rourke, M. F., Kon, N. D. (2001). Prospective Evaluation of a Method for Estimating Ascending Aortic Pressure From the Radial Artery Pressure Waveform. Hypertension 38: 932-937 [Abstract] [Full Text]