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Previous Volume 343:732-734 September 7, 2000 Number 10 Next

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Approaches involving the blockade of inflammatory cytokines such as interleukin-1 and tumor necrosis factor (TNF-) are entering mainstream clinical medicine: antibodies against TNF- and soluble receptors for TNF- are being used to treat rheumatoid arthritis and Crohn's disease. A large number of preclinical studies form the scientific basis for these anticytokine-based therapies. In experiments in animals in which a disease involving several cytokines has been induced, administration of neutralizing antibodies or the use of other means to block the biologic activity of a specific cytokine attenuates the effects of the disease or halts its progression.

A novel approach to . . . [Full Text of this Article]

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