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Editorial
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Volume 343:803-805 September 14, 2000 Number 11
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Perinatal Exposure to Zidovudine — Benefits and Risks

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 by Lipshultz, S. E.
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Mother-to-child transmission of the human immunodeficiency virus (HIV) causes a chronic and ultimately fatal pediatric infection that is now essentially preventable with antiretroviral prophylaxis. In more developed countries, prophylaxis has dramatically reduced perinatal transmission, and the potential now exists to extend this success to less developed countries by the use of effective but shorter and less expensive antiretroviral regimens. However, all regimens of antiretroviral prophylaxis require administration to the mother during pregnancy, to the neonate after birth, or both. For the large number of infants now protected from HIV infection by antiretroviral prophylaxis, the prevention of the transmission of a . . . [Full Text of this Article]

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