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Review Article
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Volume 343:864-869 September 21, 2000 Number 12
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Thromboangiitis Obliterans (Buerger's Disease)
Jeffrey W. Olin, D.O.

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Thromboangiitis obliterans (Buerger's disease) is a nonatherosclerotic segmental inflammatory disease that most commonly affects the small and medium-sized arteries, veins, and nerves of the arms and legs.1 Von Winiwarter first described a patient with thromboangiitis obliterans in 1879.2 Twenty-nine years later, Leo Buerger provided a detailed and accurate description of the pathological findings in 11 amputated limbs.3 Thromboangiitis obliterans differs from other forms of vasculitis in some important ways. Pathologically, there is a highly cellular and inflammatory thrombus with relative sparing of the blood-vessel wall. The acute-phase reactants (as assessed by the Westergren sedimentation rate and serum C-reactive protein level) . . . [Full Text of this Article]

Cause and Pathogenesis

Pathological Findings

Clinical Features

Laboratory and Arteriographic Findings

Diagnostic Criteria

Treatment


Source Information

From the Heart and Vascular Institute of New Jersey, Morristown.

Address reprint requests to Dr. Olin at the Heart and Vascular Institute of New Jersey, 111 Madison Ave., Morristown, NJ 07960, or at olinjw1@aol.com.

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