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Previous Volume 343:1194-1197 October 19, 2000 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Pocock, S. J. Related Article by Fisher, R. I. Related Article by Gottlieb, S. S. Related Article by Concato, J. PubMed Citation

To the Editor: In the June 22 issue, Concato et al.¹ compared 5 systematic reviews of randomized, controlled trials and observational studies on the same topic, and Benson and Hartz² evaluated 18 case studies of randomized, controlled trials and observational studies of different interventions and 3 reviews of randomized, controlled trials and observational studies of the same intervention. Do these data constitute a representative sample of all available comparisons in the medical literature? We think not. We know of at least two systematic reviews^3,4 in which observational studies detected effects that were not supported by randomized, controlled trials. It would . . . [Full Text of this Article]

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