Myocarditis is defined clinically as inflammation of the heartmuscle. First introduced into the medical literature at thebeginning of the 19th century, the term "myocarditis" was initiallyused to describe diseases of the heart muscle not associatedwith valvular abnormalities.1 With the recognition of the importanceof coronary-artery occlusion as a cause of heart-muscle diseaseat the beginning of the 20th century, the term was largely discarded.In the second half of the 20th century, a constellation of clinicalobservations renewed interest in inflammation of the heart muscle:myocarditis was recognized in a surprisingly large number ofpostmortem studies2. . . [Full Text of this Article]
Epidemiology
Causation
Lessons from Animal Models of Myocarditis
Pathobiology in Humans
Diagnosis
Treatment
Conclusions
Source Information
From the Cardiovascular Institute, University of Pittsburgh School of Medicine, Pittsburgh.
Address reprint requests to Dr. Feldman at the Cardiovascular Institute, UPMC Health System, 200 Lothrop St., S-572 Scaife Hall, Pittsburgh, PA 15213, or at feldmanam@msx.upmc.edu.
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