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Volume 343:1422-1423 November 9, 2000 Number 19
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Hypotensive Transfusion Reactions in Patients Taking Angiotensin-Converting–Enzyme Inhibitors

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by Goodnough, L. T.
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To the Editor: Noninfectious adverse events from blood transfusion are relatively common. They range from febrile, nonhemolytic reactions and mild allergic reactions to serious hemolytic and anaphylactic reactions.1 Hypotensive reactions to transfusion are less well recognized.2,3 They involve unexpected severe hypotension after the administration of blood through a bedside leukoreduction filter in patients taking angiotensin-converting–enzyme (ACE) inhibitors. I report a series of eight patients (Table 1) who had such reactions during a five-month period at a tertiary care hospital. During this period, 5527 units of red cells and 2206 random-donor platelet concentrates were transfused; universal leukoreduction with use . . . [Full Text of this Article]

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