FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 343:135-136 July 13, 2000 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Lichtenstein, P. PubMed Citation

The relative roles of genetic constitution and environmental exposure in the causation of cancer have been debated for decades.¹ Geographic differences, trends over time in the risk of cancer, and detailed studies of migrant populations overwhelmingly implicate environmental exposures as major causal factors and often identify the responsible carcinogens (e.g., tobacco, alcohol, radiation, occupational toxins, infections, diet, drugs). From this work has come the widely accepted estimate that 80 to 90 percent of human cancer is due to environmental factors.² Yet in the past 15 years, the explosion of molecular genetics has overshadowed environmental explanations by revealing genetic mechanisms underlying . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Toh, C.-K., Lim, W.-T. (2007). Lung cancer in never-smokers. J. Clin. Pathol. 60: 337-340 [Full Text]  
• Huang, M., Dinney, C. P., Lin, X., Lin, J., Grossman, H. B., Wu, X. (2007). High-Order Interactions among Genetic Variants in DNA Base Excision Repair Pathway Genes and Smoking in Bladder Cancer Susceptibility. Cancer Epidemiol. Biomarkers Prev. 16: 84-91 [Abstract] [Full Text]  
• Khoury, M. J., Davis, R., Gwinn, M., Lindegren, M. L., Yoon, P. (2005). Do We Need Genomic Research for the Prevention of Common Diseases with Environmental Causes?. Am J Epidemiol 161: 799-805 [Abstract] [Full Text]  
• Grigorenko, E. L. (2005). The Inherent Complexities of Gene-Environment Interactions. Journals of Gerontology Series B: Psychological Sciences and Social Science 60: 53-64 [Abstract] [Full Text]  
• Mike, V. (2003). Evidence and the Future of Medicine. Eval Health Prof 26: 127-152 [Abstract]  
• Caporaso, N. E. (2002). Why Have We Failed to Find the Low Penetrance Genetic Constituents of Common Cancers?. Cancer Epidemiol. Biomarkers Prev. 11: 1544-1549 [Full Text]  
• Hemminki, K., Risch, N. (2002). Correspondence re: Risch, N.: Genetic Epidemiology of Cancer: Interpreting Family and Twin Studies and Their Implications for Molecular Genetic Approaches. Cancer Epidemiol. Biomark. Prev., 10: 733-741, 2001.. Cancer Epidemiol. Biomarkers Prev. 11: 423-426 [Full Text]  
• HUNT, C. E. (2001). Sudden Infant Death Syndrome and Other Causes of Infant Mortality . Diagnosis, Mechanisms, and Risk for Recurrence in Siblings. Am. J. Respir. Crit. Care Med. 164: 346-357 [Full Text]  
• Risch, N. (2001). The Genetic Epidemiology of Cancer: Interpreting Family and Twin Studies and Their Implications for Molecular Genetic Approaches. Cancer Epidemiol. Biomarkers Prev. 10: 733-741 [Abstract] [Full Text]  
• Sotos, J. G., Rienhoff, H. Y., Block, G. D., Aulisio, M. P., Khoury, M. J., Ference, B. A., Chauhan, M. S., Izumo, S., Holtzman, N. A., Marteau, T. M. (2000). Will Genetics Revolutionize Medicine?. NEJM 343: 1496-1498 [Full Text]