On both sides of the Atlantic, revolutionary claims have beenmade about the ultimate impact of genetics on clinical medicine.John Bell at Oxford has asserted that "within the next decadegenetic testing will be used widely for predictive testing inhealthy people and for diagnosis and management of patients.. . . The excitement in the field has shifted to the elucidationof the genetic basis of the common diseases."1 And in the UnitedStates the director of the National Human Genome Research Institute,Francis Collins, has stated that the good that would come frommapping the human genetic . . . [Full Text of this Article]
Penetrance
Tailoring Treatments to Genotypes
The Magnitude of Absolute, Relative, and Attributable Risks
The Degree of Public Interest in Learning about Disease Risks
Conclusions
References
Related Letters:
Will Genetics Revolutionize Medicine?
Sotos J. G., Rienhoff H. Y., Block G. D., Aulisio M. P., Khoury M. J., Ference B. A., Chauhan M. S., Izumo S., Holtzman N. A., Marteau T. M.
Extract |
Full Text
N Engl J Med 2000;
343:1496-1498, Nov 16, 2000.
Correspondence
This article has been cited by other articles:
Pharoah, P. D.P., Antoniou, A. C., Easton, D. F., Ponder, B. A.J.
(2008). Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer. NEJM
358: 2796-2803
[Abstract][Full Text]
Holtzman, N. A
(2007). The strange malady of Alessandro's uncle. BMJ
335: 1306-1307
[Full Text]
Li, Y., Zagato, L., Kuznetsova, T., Tripodi, G., Zerbini, G., Richart, T., Thijs, L., Manunta, P., Wang, J.-G., Bianchi, G., Staessen, J. A.
(2007). Angiotensin-Converting Enzyme I/D and {alpha}-Adducin Gly460Trp Polymorphisms: From Angiotensin-Converting Enzyme Activity to Cardiovascular Outcome. Hypertension
49: 1291-1297
[Abstract][Full Text]
Khoury, M. J, Little, J., Gwinn, M., Ioannidis, J. P.
(2007). On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Int J Epidemiol
36: 439-445
[Abstract][Full Text]
Horst, M.
(2007). Public Expectations of Gene Therapy: Scientific Futures and Their Performative Effects on Scientific Citizenship. Science Technology Human Values
32: 150-171
[Abstract]
Hall, W. D
(2007). A research agenda for assessing the potential contribution of genomic medicine to tobacco control. Tobacco Control
16: 53-58
[Abstract][Full Text]
Petersen, A.
(2006). The genetic conception of health: is it as radical as claimed?. Health (London)
10: 481-500
[Abstract]
Ioannidis, J. P. A., Trikalinos, T. A., Khoury, M. J.
(2006). Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases. Am J Epidemiol
164: 609-614
[Abstract][Full Text]
Li, Y., Thijs, L., Kuznetsova, T., Zagato, L., Struijker-Boudier, H., Bianchi, G., Staessen, J. A.
(2005). Cardiovascular Risk in Relation to {alpha}-Adducin Gly460Trp Polymorphism and Systolic Pressure: A Prospective Population Study. Hypertension
46: 527-532
[Abstract][Full Text]
Kerruish, N J, Robertson, S P
(2005). Newborn screening: new developments, new dilemmas. J. Med. Ethics
31: 393-398
[Abstract][Full Text]
Halliday, J. L, Collins, V. R, Aitken, M. A., Richards, M. P M, Olsson, C. A
(2004). Genetics and public health--evolution, or revolution?. J. Epidemiol. Community Health
58: 894-899
[Abstract][Full Text]
Juengst, E. T.
(2004). FACE Facts: Why Human Genetics Will Always Provoke Bioethics. J Law Med Ethics
32: 267-275
Peters, N., Rose, A., Armstrong, K.
(2004). The Association between Race and Attitudes about Predictive Genetic Testing. Cancer Epidemiol. Biomarkers Prev.
13: 361-365
[Abstract][Full Text]
Stevens, J.
(2003). Racial Meanings and Scientific Methods: Changing Policies for NIH-Sponsored Publications Reporting Human Variation. Journal of Health Politics, Policy and Law
28: 1033-1088
[Abstract]
Knottnerus, J.
(2003). Community genetics and community medicine. Fam Pract
20: 601-606
[Abstract][Full Text]
Col, N. F.
(2003). The Use of Gene Tests to Detect Hereditary Predisposition to Chronic Disease: Is Cost-Effectiveness Analysis Relevant?. Med Decis Making
23: 441-448
[Abstract]
Mike, V.
(2003). Evidence and the Future of Medicine. Eval Health Prof
26: 127-152
[Abstract]
Little, J., Khoury, M. J., Bradley, L., Clyne, M., Gwinn, M., Lin, B., Lindegren, M.-L., Yoon, P.
(2003). The Human Genome Project Is Complete. How Do We Develop a Handle for the Pump?. Am J Epidemiol
157: 667-673
[Full Text]
Cooper, R. S., Psaty, B. M.
(2003). Genomics and Medicine: Distraction, Incremental Progress, or the Dawn of a New Age?. ANN INTERN MED
138: 576-580
[Abstract][Full Text]
Porta, M.
(2003). The genome sequence is a jazz score. Int J Epidemiol
32: 29-31
[Full Text]
Peters, R. J.G., Boekholdt, S. M.
(2002). Gene Polymorphisms and the Risk of Myocardial Infarction -- An Emerging Relation. NEJM
347: 1963-1965
[Full Text]
Burke, W.
(2002). Genetic Testing. NEJM
347: 1867-1875
[Full Text]
Ruilope, L. M.
(2002). The Kidney as a Sensor of Cardiovascular Risk in Essential Hypertension. J. Am. Soc. Nephrol.
13: S165-168
[Abstract][Full Text]
Gollust, S. E., Hull, S. C., Wilfond, B. S.
(2002). Limitations of Direct-to-Consumer Advertising for Clinical Genetic Testing. JAMA
288: 1762-1767
[Abstract][Full Text]
Holtzman, N A
(2002). Genetics and social class. J. Epidemiol. Community Health
56: 529-535
[Abstract][Full Text]
Hall, W, Madden, P, Lynskey, M
(2002). The genetics of tobacco use: methods, findings and policy implications. Tobacco Control
11: 119-124
[Abstract][Full Text]
Rees, J.
(2002). Complex Disease and the New Clinical Sciences. Science
296: 698-700
[Abstract][Full Text]
Frimat, L., Kessler, M.
(2002). Controversies concerning the importance of genetic polymorphism in IgA nephropathy. Nephrol Dial Transplant
17: 542-545
[Full Text]
Austin, M. A.
(2002). Ethical Issues in Human Genome Epidemiology: A Case Study Based on The Japanese American Family Study in Seattle, Washington. Am J Epidemiol
155: 585-592
[Abstract][Full Text]
Swynghedauw, B.
(2002). Susceptibility-conferring polymorphic genotypes in cardiovascular multifactorial syndromes. Eur Heart J
23: 271-273
[Full Text]
Murphy, W. M.
(2002). Human Carcinogenesis, the New Genetics, and the Practicing Pathologist. INT J SURG PATHOL
10: 1-5
[Abstract]
Phillips, K. A., Veenstra, D. L., Oren, E., Lee, J. K., Sadee, W.
(2001). Potential Role of Pharmacogenomics in Reducing Adverse Drug Reactions: A Systematic Review. JAMA
286: 2270-2279
[Abstract][Full Text]
Goldie, S. J., Levin, A. R.
(2001). Genomics in Medicine and Public Health: Role of Cost-effectiveness Analysis. JAMA
286: 1637-1638
[Full Text]
Bovet, P., Paccaud, F., McLeod, H. L., Masoudi, F. A., Havranek, E. P., Ofili, E., Flack, J., Gibbons, G., Exner, D. V., Domanski, M. J., Cohn, J. N., Schwartz, R. S.
(2001). Race and Responsiveness to Drugs for Heart Failure. NEJM
345: 766-768
[Full Text]
Kumanyika, S. K., Morssink, C. B., Nestle, M.
(2001). Minority Women and Advocacy for Women's Health. Am. J. Public Health
91: 1383-1392
[Abstract][Full Text]
Blumenthal, H. T.
(2001). Milestone or Genomania? The Relevance of the Human Genome Project to Biological Aging and the Age-Related Diseases. J. Gerontol. A Biol. Sci. Med. Sci.
56: M529-537
[Full Text]
HUNT, C. E.
(2001). Sudden Infant Death Syndrome and Other Causes of Infant Mortality . Diagnosis, Mechanisms, and Risk for Recurrence in Siblings. Am. J. Respir. Crit. Care Med.
164: 346-357
[Full Text]
Davidoff, F.
(2001). The Heartbreak of Drug Pricing. ANN INTERN MED
134: 1068-1071
[Full Text]
HEFLER, L. A., TEMPFER, C. B., GREGG, A. R.
(2001). Polymorphisms Within the Interleukin-1{beta} Gene Cluster and Preeclampsia. Obstet Gynecol
97: 664-668
[Abstract][Full Text]
Zimmern, R., Emery, J., Richards, T.
(2001). Putting genetics in perspective. BMJ
322: 1005-1006
[Full Text]
Emery, J., Hayflick, S.
(2001). The challenge of integrating genetic medicine into primary care. BMJ
322: 1027-1030
[Full Text]
Sturgis, E. M., Dahlstrom, K. R., Guan, Y., Eicher, S. A., Strom, S. S., Spitz, M. R., Wei, Q.
(2001). Alcohol Dehydrogenase 3 Genotype Is Not Associated with Risk of Squamous Cell Carcinoma of the Oral Cavity and Pharynx. Cancer Epidemiol. Biomarkers Prev.
10: 273-275
[Abstract][Full Text]
Lenfant, C.
(2001). Cardiovascular Research : A Look Into Tomorrow. Circ. Res.
88: 253-255
[Full Text]
Sotos, J. G., Rienhoff, H. Y., Block, G. D., Aulisio, M. P., Khoury, M. J., Ference, B. A., Chauhan, M. S., Izumo, S., Holtzman, N. A., Marteau, T. M.
(2000). Will Genetics Revolutionize Medicine?. NEJM
343: 1496-1498
[Full Text]
N. Re, R.
(2000). On the Sequencing of the Human Genome. Hypertension
36: 469-470
[Full Text]