FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 343:1486-1487 November 16, 2000 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Confavreux, C. PubMed Citation

Multiple sclerosis is the most common cause of severe neurologic disability in adults of northern European origin. At postmortem examination, the cardinal pathological features are multiple areas of focal loss of myelin with relative preservation of axons, a variable amount of inflammation, and astrocytic gliosis. There is general agreement that multiple sclerosis is an autoimmune disorder, although recent studies have raised the possibility that there is more than one pathway to the final pathological changes and that different pathways may predominate in different clinical forms of multiple sclerosis.¹

What are the characteristics of the different forms of multiple sclerosis? At . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Mildner, A., Mack, M., Schmidt, H., Bruck, W., Djukic, M., Zabel, M. D., Hille, A., Priller, J., Prinz, M. (2009). CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 132: 2487-2500 [Abstract] [Full Text]  
• Petzold, A, Eikelenboom, M J, Keir, G, Grant, D, Lazeron, R H C, Polman, C H, Uitdehaag, B M J, Thompson, E J, Giovannoni, G (2005). Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study. J. Neurol. Neurosurg. Psychiatry 76: 206-211 [Abstract] [Full Text]  
• Adalsteinsson, E., Langer-Gould, A., Homer, R. J., Rao, A., Sullivan, E. V., Lima, C. A., Pfefferbaum, A., Atlas, S. W. (2003). Gray Matter N-Acetyl Aspartate Deficits in Secondary Progressive but Not Relapsing-Remitting Multiple Sclerosis. Am. J. Neuroradiol. 24: 1941-1945 [Abstract] [Full Text]  
• Rice, G P. (2002). The natural history of secondary progressive multiple sclerosis: observations from the London study group. Mult Scler 8: 81-82  
• (2001). Relapse, Remission, and Disability Progression in Multiple Sclerosis. JWatch Neurology 2001: 4-4 [Full Text]