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Previous Volume 343:1496-1498 November 16, 2000 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We find two major flaws in the Sounding Board article by Holtzman and Marteau (July 13 issue).¹ First, if the authors find little clinical value in the genetics revolution, then they must find no value in taking a family history — a conclusion surely at odds with the experience of Hippocrates² and 95 subsequent generations of physicians. Holtzman and Marteau rightly focus on the genetics of common diseases, but they restrict their analysis to the diagnostic use of isolated genetic information. They do not consider the full Bayesian framework on which modern methods of diagnosis are based. . . . [Full Text of this Article]

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