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Previous Volume 343:1603-1607 November 30, 2000 Number 22 Next

	Full Text PDF Editorial by Woolf, S. H. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Both annual testing for fecal occult blood and biennial testing significantly reduce mortality from colorectal cancer. However, the effect of screening on the incidence of colorectal cancer remains uncertain, despite the diagnosis and removal of precancerous lesions in many persons who undergo screening.

Methods We have followed the participants in the Minnesota Colon Cancer Control Study for 18 years. A total of 46,551 people, most of whom were 50 to 80 years old, were enrolled between 1975 and 1978 and randomly assigned to annual screening, biennial screening, or usual care (the control group). Those assigned to the screening groups were asked to prepare and submit two samples from each of three consecutive stools for guaiac-based testing. Those with at least one positive slide in the set of six were offered a diagnostic examination that included colonoscopy. Screening was conducted between 1976 and 1982 and again between 1986 and 1992. Study participants have been followed with respect to newly diagnosed cases of colorectal cancer and deaths. Follow-up has been more than 90 percent complete.

Results During the 18-year follow-up period, we identified 1359 new cases of colorectal cancer: 417 in the annual-screening group, 435 in the biennial-screening group, and 507 in the control group. The cumulative incidence ratios for colorectal cancer in the screening groups as compared with the control group were 0.80 (95 percent confidence interval, 0.70 to 0.90) and 0.83 (95 percent confidence interval, 0.73 to 0.94) for the annual-screening and biennial-screening groups, respectively. For both screening groups, the number of positive slides was associated with the positive predictive value both for colorectal cancer and for adenomatous polyps at least 1 cm in diameter.

Conclusions The use of either annual or biennial fecal occult-blood testing significantly reduces the incidence of colorectal cancer.

Source Information

From Exponent, Menlo Park, Calif. (J.S.M.); the Divisions of Environmental and Occupational Health (T.R.C., M.S.G., S.J.M.), Biostatistics (F.E.), and Epidemiology (L.M.S.), School of Public Health, University of Minnesota, Minneapolis; the Minneapolis Veterans Affairs Hospital, Minneapolis (J.H.B.); the Emmes Corp., Potomac, Md. (F.E.); and Fairview Hospital, Minneapolis (D.C.S.).

Address reprint requests to Dr. Mandel at Exponent, 149 Commonwealth Dr., Menlo Park, CA 94025, or at jmandel{at}exponent.com.

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