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Previous Volume 343:1627-1633 November 30, 2000 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Lung cancer is the leading cause of death from cancer among men and women in the United States. More people die each year of lung cancer than of colon, breast, and prostate cancer combined. Despite new diagnostic techniques, the overall five-year survival rates remain about 14 percent, and most patients still present with advanced disease.¹

There has long been interest in screening to detect lung cancers when they are smaller and presumably at earlier and more curable stages, as witnessed by the support for previous screening trials using chest radiography and cytologic examination of sputum. Unfortunately, these studies failed to . . . [Full Text of this Article]

Some Fundamentals about Screening

Prior Screening Trials

Current Early-Detection and Screening Trials

Imaging Studies

Nonimaging Methods of Early Detection

Potential Biologic Limitations in Screening for Lung Cancer

Current Recommendations

Source Information

From the Department of Radiology, Duke University Medical Center, Durham, N.C. (E.F.P., P.C.G.); and the Departments of Medicine and Cancer Genetics, Roswell Park Cancer Institute, Buffalo, N.Y. (G.B.).

Address reprint requests to Dr. Patz at the Department of Radiology, Box 3808, Duke University Medical Center, Durham, NC 27710, or at patz0002@mc.duke.edu.

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