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Previous Volume 343:1643-1645 November 30, 2000 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Any clinical investigator will tell you that the success of a clinical trial is limited by the ability to recruit patients to become research subjects. Altruism aside, many patients who make this transition reach a conscious and informed decision to forgo standard care or even forgo treatment altogether for the chance, but only a chance, that they may benefit from an as yet unproved drug, device, or procedure. The decision takes special courage, and medical science is grateful to the people who display this courage.

The investigational treatment received under a research protocol may be no better than the standard . . . [Full Text of this Article]

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