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Previous Volume 343:1697-1701 December 7, 2000 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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MÉnÉtrier's disease (hypoproteinemic hypertrophic gastropathy) is a rare, acquired, premalignant disorder of the stomach.^1,2,3,4 It is characterized by giant hypertrophic folds that most often involve the fundus, excess mucus secretion, decreased acid secretion (hypochlorhydria), and hypoproteinemia due to selective loss of serum proteins across the gastric mucosa.^5,6 The cause of Ménétrier's disease is unknown, although infection with cytomegalovirus (CMV) in children and infection with Helicobacter pylori have been implicated.^7,8 Symptoms include epigastric pain, vomiting, edema, anorexia, and weight loss. Gastric cancer has been reported at diagnosis or during follow-up in patients with hypertrophic gastropathy. Evidence of the benefits of anticholinergic . . . [Full Text of this Article]

Case Report

Results

Discussion

Source Information

From the Departments of Medicine and Pathology, University of Texas Southwestern Medical Center, Dallas (J.S.B.); the Departments of Pathology, Medicine, and Cell Biology, Vanderbilt University School of Medicine and Nashville Veterans Affairs Medical Center, Nashville (E.C., G.T., K.W., R.J.C.); the Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa (M.S., J.E.P., J.Q.C.); and the Augusta Veterans Affairs Medical Center and Departments of Medicine, Surgery, and Cellular Biology and Anatomy, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta (J.R.G.).

Address reprint requests to Dr. Coffey at CC-2201 Medical Center North, Vanderbilt University, Nashville, TN 37232, or at coffeyrj@ctrvax.vanderbilt.edu.

References

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• Rothenberg, M. L., LaFleur, B., Levy, D. E., Washington, M. K., Morgan-Meadows, S. L., Ramanathan, R. K., Berlin, J. D., Benson, A. B. III, Coffey, R. J. (2005). Randomized Phase II Trial of the Clinical and Biological Effects of Two Dose Levels of Gefitinib in Patients With Recurrent Colorectal Adenocarcinoma. JCO 23: 9265-9274 [Abstract] [Full Text]  
• Elinav, E, Korem, M, Ofran, Y, Migdal, A, Doviner, V, Hiler, N, Aamar, S, Bursztyn, M (2004). Hyperplastic gastropathy as a presenting manifestation of systemic lupus erythematosus. Lupus 13: 60-63 [Abstract]  
• van den Brink, G R, Hardwick, J C H, Nielsen, C, Xu, C, ten Kate, F J, Glickman, J, van Deventer, S J H, Roberts, D J, Peppelenbosch, M P (2003). Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Mol. Pathol. 56: 150-155 [Abstract] [Full Text]  
• van den Brink, G R, Hardwick, J C H, Nielsen, C, Xu, C, ten Kate, F J, Glickman, J, van Deventer, S J H, Roberts, D J, Peppelenbosch, M P (2002). Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 51: 628-633 [Abstract] [Full Text]