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Correspondence
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Volume 343:1891-1894 December 21, 2000 Number 25
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Coronary Heart Disease in Women

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 by Herrington, D. M.
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 by Hu, F. B.
To the Editor: We would view with caution the conclusion of Herrington and colleagues (Aug. 24 issue)1 that women with established coronary heart disease should not use estrogen replacement with an expectation of a cardiovascular benefit. The results of their study apply only to the use of conjugated equine estrogens at a dose of 0.625 mg daily, alone or in combination with medroxyprogesterone acetate. Their findings may not be relevant to other estrogens and progestogens used in hormone-replacement therapy.

The effects of estrogens on the risk of cardiovascular disease vary according to the type of estrogen, the dose, and the . . . [Full Text of this Article]

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