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Volume 343:1899-1900 December 21, 2000 Number 25
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Hepatitis C

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(Biomedical Research Reports.) Edited by T. Jake Liang and Jay H. Hoofnagle. 493 pp., illustrated. San Diego, Calif., Academic Press, 2000. $99.95. ISBN 0-12-447870-0.

Hepatitis C virus (HCV) infection is a major health problem worldwide. About 100 million to 150 million people are infected, including approximately 4 million to 5 million in western Europe and 3 million to 4 million in the United States. Approximately 60 to 70 percent of those infected have chronic hepatitis, and 15 to 20 percent have cirrhosis, which may evolve into hepatocellular carcinoma. Although disease caused by HCV infection progresses slowly and usually takes more than 20 to 30 years to develop into clinically overt liver disease, the number of cases is expected to increase sharply during the next . . . [Full Text of this Article]




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