Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography
Remge M. Pieterman, M.D., John W.G. van Putten, M.D., Jacobus J. Meuzelaar, M.D., Eduard L. Mooyaart, M.D., Willem Vaalburg, Ph.D., Gerard H. Koëter, M.D., Vaclav Fidler, Ph.D., Jan Pruim, M.D., and Harry J.M. Groen, M.D.
Background Determining the stage of non–small-cell lungcancer often requires multiple preoperative tests and invasiveprocedures. Whole-body positron-emission tomography (PET) maysimplify and improve the evaluation of patients with this tumor.
Methods We prospectively compared the ability of a standardapproach to staging (computed tomography [CT], ultrasonography,bone scanning, and, when indicated, needle biopsies) and oneinvolving PET to detect metastases in mediastinal lymph nodesand at distant sites in 102 patients with resectable non–small-celllung cancer. The presence of mediastinal metastatic diseasewas confirmed histopathologically. Distant metastases that weredetected by PET were further evaluated by standard imaging testsand biopsies. Patients were followed postoperatively for sixmonths by standard methods to detect occult metastases. Logistic-regressionanalysis was used to evaluate the ability of PET and CT to identifymalignant mediastinal lymph nodes.
Results The sensitivity and specificity of PET for the detectionof mediastinal metastases were 91 percent (95 percent confidenceinterval, 81 to 100 percent) and 86 percent (95 percent confidenceinterval, 78 to 94 percent), respectively. The correspondingvalues for CT were 75 percent (95 percent confidence interval,60 to 90 percent) and 66 percent (95 percent confidence interval,55 to 77 percent). When the results of PET and CT were adjustedfor each other, only PET results were positively correlatedwith the histopathological findings in mediastinal lymph nodes(P<0.001). PET identified distant metastases that had notbeen found by standard methods in 11 of 102 patients. The sensitivityand specificity of PET for the detection of both mediastinaland distant metastatic disease were 95 percent (95 percent confidenceinterval, 88 to 100 percent) and 83 percent (95 percent confidenceinterval, 74 to 92 percent), respectively. The use of PET forclinical staging resulted in a different stage from the onedetermined by standard methods in 62 patients: the stage waslowered in 20 and raised in 42.
Conclusions PET improves the rate of detection of local anddistant metastases in patients with non–small-cell lungcancer.
Source Information
From the Departments of Pulmonary Diseases (R.M.P., J.W.G.P., G.H.K., H.J.M.G.), Thoracic Surgery (J.J.M.), Radiology (E.L.M.), and Biostatistics and Epidemiology (V.F.) and the Positron-Emission Tomography Center (R.M.P., W.V., J.P.), Groningen University Hospital, Groningen, the Netherlands. Presented in part at the International Conference of the American Thoracic Society–American Lung Association, San Diego, Calif., April 23–28, 1999, and at the Annual Meeting of the American Society of Clinical Oncology, Atlanta, May 15–18, 1999.
Address reprint requests to Dr. Groen at the Department of Pulmonary Diseases, Groningen University Hospital, Hanzeplein 1, 9700 RB Groningen, the Netherlands, or at h.j.m.groen{at}int.azg.nl.
Kaira, K., Oriuchi, N., Shimizu, K., Tominaga, H., Yanagitani, N., Sunaga, N., Ishizuka, T., Kanai, Y., Mori, M., Endo, K.
(2009). 18F-FMT Uptake Seen Within Primary Cancer on PET Helps Predict Outcome of Non-Small Cell Lung Cancer. JNM
50: 1770-1776
[Abstract][Full Text]
Defranchi, S. A., Cassivi, S. D., Nichols, F. C., Allen, M. S., Shen, K. R., Deschamps, C., Wigle, D. A.
(2009). N2 disease in T1 non-small cell lung cancer.. Ann. Thorac. Surg.
88: 924-928
[Abstract][Full Text]
Maziak, D. E., Darling, G. E., Inculet, R. I., Gulenchyn, K. Y., Driedger, A. A., Ung, Y. C., Miller, J. D., Gu, C.-S., Cline, K. J., Evans, W. K., Levine, M. N.
(2009). Positron Emission Tomography in Staging Early Lung Cancer: A Randomized Trial. ANN INTERN MED
151: 221-228
[Abstract][Full Text]
Hwangbo, B., Kim, S. K., Lee, H.-S., Lee, H. S., Kim, M. S., Lee, J. M., Kim, H.-Y., Lee, G.-K., Nam, B.-H., Zo, J. I.
(2009). Application of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Following Integrated PET/CT in Mediastinal Staging of Potentially Operable Non-small Cell Lung Cancer. Chest
135: 1280-1287
[Abstract][Full Text]
Erasmus, J. J., Rohren, E., Swisher, S. G.
(2009). Prognosis and Reevaluation of Lung Cancer by Positron Emission Tomography Imaging. Proc Am Thorac Soc
6: 171-179
[Abstract][Full Text]
Farjah, F., Flum, D. R., Varghese, T. K. Jr, Symons, R. G., Wood, D. E.
(2009). Surgeon Specialty and Long-Term Survival After Pulmonary Resection for Lung Cancer. Ann. Thorac. Surg.
87: 995-1006
[Abstract][Full Text]
Ben-Haim, S., Ell, P.
(2009). 18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response. JNM
50: 88-99
[Abstract][Full Text]
de Jong, W K, Schaapveld, M, Blaauwgeers, J L G, Groen, H J M
(2008). Pulmonary tumours in the Netherlands: focus on temporal trends in histology and stage and on rare tumours. Thorax
63: 1096-1102
[Abstract][Full Text]
FUWA, N, DAIMON, T, MITSUDOMI, T, YATABE, Y, KODAIRA, T, TACHIBANA, H, NAKAMURA, T, KATO, T, SATO, Y
(2008). Identifying patients with peripheral-type early non-small cell lung cancer (T1N0M0) for whom irradiation of the primary focus alone could lead to successful treatment. Br. J. Radiol.
81: 815-820
[Abstract][Full Text]
Bordoni, R.
(2008). Consensus Conference: Multimodality Management of Early- and Intermediate-Stage Non-Small Cell Lung Cancer. The Oncologist
13: 945-953
[Abstract][Full Text]
Yi, C. A, Shin, K. M., Lee, K. S., Kim, B.-T., Kim, H., Kwon, O J., Choi, J. Y., Chung, M. J.
(2008). Non-Small Cell Lung Cancer Staging: Efficacy Comparison of Integrated PET/CT versus 3.0-T Whole-Body MR Imaging. Radiology
248: 632-642
[Abstract][Full Text]
Chee, K. G., Nguyen, D. V., Brown, M., Gandara, D. R., Wun, T., Lara, P. N. Jr
(2008). Positron Emission Tomography and Improved Survival in Patients With Lung Cancer: The Will Rogers Phenomenon Revisited. Arch Intern Med
168: 1541-1549
[Abstract][Full Text]
Hanin, F.-X., Lonneux, M., Cornet, J., Noirhomme, P., Coulon, C., Distexhe, J., Poncelet, A. J.
(2008). Prognostic value of FDG uptake in early stage non-small cell lung cancer. Eur. J. Cardiothorac. Surg.
33: 819-823
[Abstract][Full Text]
Molina, J. R., Yang, P., Cassivi, S. D., Schild, S. E., Adjei, A. A.
(2008). Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship. Mayo Clin Proc.
83: 584-594
[Abstract][Full Text]
Kozower, B. D., Meyers, B. F., Reed, C. E., Jones, D. R., Decker, P. A., Putnam, J. B. Jr
(2008). Does Positron Emission Tomography Prevent Nontherapeutic Pulmonary Resections for Clinical Stage IA Lung Cancer?. Ann. Thorac. Surg.
85: 1166-1170
[Abstract][Full Text]
Silvestri, G A, Spiro, S G
(2008). Carcinoma of the bronchus 60 years later. Postgrad. Med. J.
84: 182-187
[Full Text]
Fletcher, J. W., Djulbegovic, B., Soares, H. P., Siegel, B. A., Lowe, V. J., Lyman, G. H., Coleman, R. E., Wahl, R., Paschold, J. C., Avril, N., Einhorn, L. H., Suh, W. W., Samson, D., Delbeke, D., Gorman, M., Shields, A. F.
(2008). Recommendations on the Use of 18F-FDG PET in Oncology. JNM
49: 480-508
[Abstract][Full Text]
Melek, H., Gunluoglu, M. Z., Demir, A., Akin, H., Olcmen, A., Dincer, S. I.
(2008). Role of positron emission tomography in mediastinal lymphatic staging of non-small cell lung cancer. Eur. J. Cardiothorac. Surg.
33: 294-299
[Abstract][Full Text]
Sung, Y. M., Lee, K. S., Kim, B.-T., Kim, S., Kwon, O J., Choi, J. Y., Yang, S.-O.
(2008). Nonpalpable Supraclavicular Lymph Nodes in Lung Cancer Patients: Preoperative Characterization with 18F-FDG PET/CT. Am. J. Roentgenol.
190: 246-252
[Abstract][Full Text]
Ung, Y. C., Maziak, D. E., Vanderveen, J. A., Smith, C. A., Gulenchyn, K., Lacchetti, C., Evans, W. K., Lung Cancer Disease Site Group of Cancer Care Onta,
(2007). 18Fluorodeoxyglucose Positron Emission Tomography in the Diagnosis and Staging of Lung Cancer: A Systematic Review. JNCI J Natl Cancer Inst
99: 1753-1767
[Abstract][Full Text]
Giaccone, G.
(2007). 18Fluorodeoxyglucose Positron Emission Tomography, a Standard Diagnostic Tool in Lung Cancer. JNCI J Natl Cancer Inst
99: 1741-1743
[Full Text]
Kaira, K., Oriuchi, N., Otani, Y., Shimizu, K., Tanaka, S., Imai, H., Yanagitani, N., Sunaga, N., Hisada, T., Ishizuka, T., Dobashi, K., Kanai, Y., Endou, H., Nakajima, T., Endo, K., Mori, M.
(2007). Fluorine-18-{alpha}-Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer: A Clinicopathologic Study. Clin. Cancer Res.
13: 6369-6378
[Abstract][Full Text]
de Geus-Oei, L.-F., van der Heijden, H. F.M., Visser, E. P., Hermsen, R., van Hoorn, B. A., Timmer-Bonte, J. N.H., Willemsen, A. T., Pruim, J., Corstens, F. H.M., Krabbe, P. F.M., Oyen, W. J.G.
(2007). Chemotherapy Response Evaluation with 18F-FDG PET in Patients with Non-Small Cell Lung Cancer. JNM
48: 1592-1598
[Abstract][Full Text]
Wang, F., Wang, Z., Yao, W., Xie, H., Xu, J., Tian, L.
(2007). Role of 99mTc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with 18F-FDG Dual-Head Coincidence Imaging. JNM
48: 1442-1448
[Abstract][Full Text]
Silvestri, G. A., Gould, M. K., Margolis, M. L., Tanoue, L. T., McCrory, D., Toloza, E., Detterbeck, F.
(2007). Noninvasive Staging of Non-small Cell Lung Cancer: ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition). Chest
132: 178S-201S
[Abstract][Full Text]
Festic, E., Abraham, P. J., Burnett, O. L., Young, P. M., Johnson, M. M.
(2007). Increased Radiotracer Uptake on Positron Emission Tomography After Invasive Thoracic Procedures: A Case Series. Mayo Clin Proc.
82: 1060-1064
[Abstract][Full Text]
Port, J. L., Lee, P. C., Korst, R. J., Liss, Y., Meherally, D., Christos, P., Mazumdar, M., Altorki, N. K.
(2007). Positron Emission Tomographic Scanning Predicts Survival After Induction Chemotherapy for Esophageal Carcinoma. Ann. Thorac. Surg.
84: 393-400
[Abstract][Full Text]
Tournoy, K G, Maddens, S, Gosselin, R, Van Maele, G, van Meerbeeck, J P, Kelles, A
(2007). Integrated FDG-PET/CT does not make invasive staging of the intrathoracic lymph nodes in non-small cell lung cancer redundant: a prospective study. Thorax
62: 696-701
[Abstract][Full Text]
Kong, F.-M. S., Frey, K. A., Quint, L. E., Haken, R. K. T., Hayman, J. A., Kessler, M., Chetty, I. J., Normolle, D., Eisbruch, A., Lawrence, T. S.
(2007). A Pilot Study of [18F]Fluorodeoxyglucose Positron Emission Tomography Scans During and After Radiation-Based Therapy in Patients With Non Small-Cell Lung Cancer. JCO
25: 3116-3123
[Abstract][Full Text]
Torigian, D. A., Huang, S. S., Houseni, M., Alavi, A.
(2007). Functional Imaging of Cancer with Emphasis on Molecular Techniques. CA Cancer J Clin
57: 206-224
[Abstract][Full Text]
Okada, M., Tauchi, S., Iwanaga, K., Mimura, T., Kitamura, Y., Watanabe, H., Adachi, S., Sakuma, T., Ohbayashi, C.
(2007). Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas. J. Thorac. Cardiovasc. Surg.
133: 1448-1454
[Abstract][Full Text]
Riedl, C. C., Akhurst, T., Larson, S., Stanziale, S. F., Tuorto, S., Bhargava, A., Hricak, H., Klimstra, D., Fong, Y.
(2007). 18F-FDG PET Scanning Correlates with Tissue Markers of Poor Prognosis and Predicts Mortality for Patients After Liver Resection for Colorectal Metastases. JNM
48: 771-775
[Abstract][Full Text]
Moghissi, K., Dixon, K., Thorpe, J. A. C., Stringer, M., Oxtoby, C.
(2007). Photodynamic therapy (PDT) in early central lung cancer: a treatment option for patients ineligible for surgical resection. Thorax
62: 391-395
[Abstract][Full Text]
Yi, C. A, Lee, K. S., Kim, B.-T., Shim, S. S., Chung, M. J., Sung, Y. M., Jeong, S. Y.
(2007). Efficacy of Helical Dynamic CT Versus Integrated PET/CT for Detection of Mediastinal Nodal Metastasis in Non-Small Cell Lung Cancer. Am. J. Roentgenol.
188: 318-325
[Abstract][Full Text]
Blodgett, T. M., Meltzer, C. C., Townsend, D. W.
(2007). PET/CT: Form and Function. Radiology
242: 360-385
[Abstract][Full Text]
Daniels, C. E., Lowe, V. J., Aubry, M.-C., Allen, M. S., Jett, J. R.
(2007). The Utility of Fluorodeoxyglucose Positron Emission Tomography in the Evaluation of Carcinoid Tumors Presenting as Pulmonary Nodules. Chest
131: 255-260
[Abstract][Full Text]
Gregoire, V., Haustermans, K., Geets, X., Roels, S., Lonneux, M.
(2007). PET-Based Treatment Planning in Radiotherapy: A New Standard?. JNM
48: 68S-77S
[Abstract][Full Text]
Silvestri, G A, Spiro, S G
(2006). Carcinoma of the bronchus 60 years later.. Thorax
61: 1023-1028
[Full Text]
Biehl, K. J., Kong, F.-M., Dehdashti, F., Jin, J.-Y., Mutic, S., El Naqa, I., Siegel, B. A., Bradley, J. D.
(2006). 18F-FDG PET Definition of Gross Tumor Volume for Radiotherapy of Non-Small Cell Lung Cancer: Is a Single Standardized Uptake Value Threshold Approach Appropriate?. JNM
47: 1808-1812
[Abstract][Full Text]
Kim, B.-T., Lee, K. S., Shim, S. S., Choi, J. Y., Kwon, O J., Kim, H., Shim, Y. M., Kim, J., Kim, S.
(2006). Stage T1 Non-Small Cell Lung Cancer: Preoperative Mediastinal Nodal Staging with Integrated FDG PET/CT--A Prospective Study. Radiology
241: 501-509
[Abstract][Full Text]
Posther, K. E., McCall, L. M., Harpole, D. H. Jr., Reed, C. E., Putnam, J. B. Jr., Rusch, V. W., Siegel, B. A.
(2006). Yield of Brain 18F-FDG PET in Evaluating Patients with Potentially Operable Non-Small Cell Lung Cancer. JNM
47: 1607-1611
[Abstract][Full Text]
Yasufuku, K., Nakajima, T., Motoori, K., Sekine, Y., Shibuya, K., Hiroshima, K., Fujisawa, T.
(2006). Comparison of Endobronchial Ultrasound, Positron Emission Tomography, and CT for Lymph Node Staging of Lung Cancer.. Chest
130: 710-718
[Abstract][Full Text]
Lee, K.-H., Lee, S.-H., Kim, D.-W., Kang, W. J., Chung, J.-K., Im, S.-A., Kim, T.-Y., Kim, Y. W., Bang, Y.-J., Heo, D. S.
(2006). High fluorodeoxyglucose uptake on positron emission tomography in patients with advanced non-small cell lung cancer on platinum-based combination chemotherapy.. Clin. Cancer Res.
12: 4232-4236
[Abstract][Full Text]
Barentsz, J., Takahashi, S., Oyen, W., Mus, R., De Mulder, P., Reznek, R., Oudkerk, M., Mali, W.
(2006). Commonly Used Imaging Techniques for Diagnosis and Staging. JCO
24: 3234-3244
[Abstract][Full Text]
Quon, A., Napel, S., Beaulieu, C. F., Gambhir, S. S.
(2006). "Flying Through" and "Flying Around" a PET/CT Scan: Pilot Study and Development of 3D Integrated 18F-FDG PET/CT for Virtual Bronchoscopy and Colonoscopy. JNM
47: 1081-1087
[Abstract][Full Text]
Lobrano, M. B.
(2006). Partnerships in Oncology and Radiology: The Role of Radiology in the Detection, Staging, and Follow-up of Lung Cancer. The Oncologist
11: 774-779
[Abstract][Full Text]
Bernasconi, M., Chhajed, P. N., Gambazzi, F., Bubendorf, L., Rasch, H., Kneifel, S., Tamm, M.
(2006). Combined transbronchial needle aspiration and positron emission tomography for mediastinal staging of NSCLC. Eur Respir J
27: 889-894
[Abstract][Full Text]
Mawlawi, O., Erasmus, J. J., Pan, T., Cody, D. D., Campbell, R., Lonn, A. H., Kohlmyer, S., Macapinlac, H. A., Podoloff, D. A.
(2006). Truncation Artifact on PET/CT: Impact on Measurements of Activity Concentration and Assessment of a Correction Algorithm.. Am. J. Roentgenol.
186: 1458-1467
[Abstract][Full Text]
Herder, G. J.M., Kramer, H., Hoekstra, O. S., Smit, E. F., Pruim, J., van Tinteren, H., Comans, E. F., Verboom, P., Uyl-de Groot, C. A., Welling, A., Paul, M. A., Boers, M., Postmus, P. E., Teule, G. J., Groen, H. J.M.
(2006). Traditional Versus Up-Front [18F] Fluorodeoxyglucose-Positron Emission Tomography Staging of Non-Small-Cell Lung Cancer: A Dutch Cooperative Randomized Study. JCO
24: 1800-1806
[Abstract][Full Text]
Hishida, T., Nagai, K., Yoshida, J., Nishimura, M., Ishii, G.-i., Iwasaki, M., Nishiwaki, Y.
(2006). Is surgical resection indicated for a solitary non-small cell lung cancer recurrence?. J. Thorac. Cardiovasc. Surg.
131: 838-842
[Abstract][Full Text]
Shim, S. S., Lee, K. S., Chung, M. J., Kim, H., Kwon, O J., Kim, S.
(2006). Do hemodynamic studies of stage t1 lung cancer enable the prediction of hilar or mediastinal nodal metastasis?. Am. J. Roentgenol.
186: 981-988
[Abstract][Full Text]
Bunyaviroch, T., Coleman, R. E.
(2006). PET Evaluation of Lung Cancer. JNM
47: 451-469
[Full Text]
Hendrickx, B. W., van Herpen, C. M.L., Bonenkamp, J. J., Bulten, J., Oyen, W. J.G.
(2005). Positive Positron Emission Tomography Scan in Sarcoidosis and Two Challenging Cases of Metastatic Cancer: CASE 1. Mediastinal Sarcoidosis in a Melanoma Patient Treated With Interferon. JCO
23: 8906-8907
[Full Text]
Port, J. L., Andrade, R. S., Levin, M. A., Korst, R. J., Lee, P. C., Becker, D. E., Altorki, N. K.
(2005). Positron emission tomographic scanning in the diagnosis and staging of non-small cell lung cancer 2 cm in size or less. J. Thorac. Cardiovasc. Surg.
130: 1611-1615
[Abstract][Full Text]
Rusch, V. W.
(2005). Mediastinoscopy: An Endangered Species?. JCO
23: 8283-8285
[Full Text]
Annema, J. T., Versteegh, M. I., Veselic, M., Voigt, P., Rabe, K. F.
(2005). Endoscopic Ultrasound-Guided Fine-Needle Aspiration in the Diagnosis and Staging of Lung Cancer and Its Impact on Surgical Staging. JCO
23: 8357-8361
[Abstract][Full Text]
Pozo-Rodriguez, F., Martin de Nicolas, J. L., Sanchez-Nistal, M. A., Maldonado, A., Garcia de Barajas, S., Calero-Garcia, R., Pozo, M. A., Martin-Escribano, P., Martin-Garcia, I., Garcia-Lujan, R., Lopez-Encuentra, A., Arenas de Pablo, A.
(2005). Accuracy of Helical Computed Tomography and [18F] Fluorodeoxyglucose Positron Emission Tomography for Identifying Lymph Node Mediastinal Metastases in Potentially Resectable Non-Small-Cell Lung Cancer. JCO
23: 8348-8356
[Abstract][Full Text]
Lardinois, D., Weder, W., Roudas, M., von Schulthess, G. K., Tutic, M., Moch, H., Stahel, R. A., Steinert, H. C.
(2005). Etiology of Solitary Extrapulmonary Positron Emission Tomography and Computed Tomography Findings in Patients With Lung Cancer. JCO
23: 6846-6853
[Abstract][Full Text]
Halpern, B. S., Schiepers, C., Weber, W. A., Crawford, T. L., Fueger, B. J., Phelps, M. E., Czernin, J.
(2005). Presurgical Staging of Non-small Cell Lung Cancer: Positron Emission Tomography, Integrated Positron Emission Tomography/CT, and Software Image Fusion. Chest
128: 2289-2297
[Abstract][Full Text]
Tournoy, K. G., Praet, M. M., Van Maele, G., Van Meerbeeck, J. P.
(2005). Esophageal Endoscopic Ultrasound With Fine-Needle Aspiration With an On-site Cytopathologist: High Accuracy for the Diagnosis of Mediastinal Lymphadenopathy. Chest
128: 3004-3009
[Abstract][Full Text]
Onn, A., Choe, D. H., Herbst, R. S., Correa, A. M., Munden, R. F., Truong, M. T., Vaporciyan, A. A., Isobe, T., Gilcrease, M. Z., Marom, E. M.
(2005). Tumor Cavitation in Stage I Non-Small Cell Lung Cancer: Epidermal Growth Factor Receptor Expression and Prediction of Poor Outcome. Radiology
237: 342-347
[Abstract][Full Text]
Shim, S. S., Lee, K. S., Kim, B.-T., Chung, M. J., Lee, E. J., Han, J., Choi, J. Y., Kwon, O J., Shim, Y. M., Kim, S.
(2005). Non-Small Cell Lung Cancer: Prospective Comparison of Integrated FDG PET/CT and CT Alone for Preoperative Staging. Radiology
236: 1011-1019
[Abstract][Full Text]
Annema, J. T., Versteegh, M. I., Veselic, M., Welker, L., Mauad, T., Sont, J. K., Willems, L. N. A., Rabe, K. F.
(2005). Endoscopic Ultrasound Added to Mediastinoscopy for Preoperative Staging of Patients With Lung Cancer. JAMA
294: 931-936
[Abstract][Full Text]
Sachs, S., Bilfinger, T. V.
(2005). The Impact of Positron Emission Tomography on Clinical Decision Making in a University-Based Multidisciplinary Lung Cancer Practice. Chest
128: 698-703
[Abstract][Full Text]
Juweid, M. E., Wiseman, G. A., Vose, J. M., Ritchie, J. M., Menda, Y., Wooldridge, J. E., Mottaghy, F. M., Rohren, E. M., Blumstein, N. M., Stolpen, A., Link, B. K., Reske, S. N., Graham, M. M., Cheson, B. D.
(2005). Response Assessment of Aggressive Non-Hodgkin's Lymphoma by Integrated International Workshop Criteria and Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography. JCO
23: 4652-4661
[Abstract][Full Text]
Cerfolio, R. J., Bryant, A. S., Ohja, B., Bartolucci, A. A.
(2005). The maximum standardized uptake values on positron emission tomography of a non-small cell lung cancer predict stage, recurrence, and survival. J. Thorac. Cardiovasc. Surg.
130: 151-159
[Abstract][Full Text]
Shankar, L. K., Sullivan, D. C.
(2005). Functional Imaging in Lung Cancer. JCO
23: 3203-3211
[Abstract][Full Text]
Ohtsuka, T., Nomori, H., Watanabe, K., Naruke, T., Orikasa, H., Yamazaki, K., Suemasu, K., Uno, K.
(2005). False-positive Findings on [18F]FDG-PET Caused by Non-neoplastic Cellular Elements After Neoadjuvant Chemoradiotherapy for Non-small Cell Lung Cancer. Jpn J Clin Oncol
35: 271-273
[Abstract][Full Text]
Kelloff, G. J., Hoffman, J. M., Johnson, B., Scher, H. I., Siegel, B. A., Cheng, E. Y., Cheson, B. D., O'Shaughnessy, J., Guyton, K. Z., Mankoff, D. A., Shankar, L., Larson, S. M., Sigman, C. C., Schilsky, R. L., Sullivan, D. C.
(2005). Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development. Clin. Cancer Res.
11: 2785-2808
[Abstract][Full Text]
Beal, K. P., Yeung, H. W., Yahalom, J.
(2005). FDG-PET scanning for detection and staging of extranodal marginal zone lymphomas of the MALT type: a report of 42 cases. Ann Oncol
16: 473-480
[Abstract][Full Text]
Erturan, S., Yaman, M., Aydin, G., Uzel, I., Musellim, B., Kaynak, K.
(2005). The Role of Whole-Body Bone Scanning and Clinical Factors in Detecting Bone Metastases in Patients With Non-small Cell Lung Cancer. Chest
127: 449-454
[Abstract][Full Text]
LeBlanc, J. K., Devereaux, B. M., Imperiale, T. F., Kesler, K., DeWitt, J. M., Cummings, O., Ciaccia, D., Sherman, S., Mathur, P., Conces, D., Brooks, J., Chriswell, M., Einhorn, L., Collins, E.
(2005). Endoscopic Ultrasound in Non-Small Cell Lung Cancer and Negative Mediastinum on Computed Tomography. Am. J. Respir. Crit. Care Med.
171: 177-182
[Abstract][Full Text]
Eloubeidi, M. A., Cerfolio, R. J., Chen, V. K., Desmond, R., Syed, S., Ojha, B.
(2005). Endoscopic Ultrasound-Guided Fine Needle Aspiration of Mediastinal Lymph Node in Patients With Suspected Lung Cancer After Positron Emission Tomography and Computed Tomography Scans. Ann. Thorac. Surg.
79: 263-268
[Abstract][Full Text]
Cerfolio, R. J., Bryant, A. S., Winokur, T. S., Ohja, B., Bartolucci, A. A.
(2004). Repeat FDG-PET After Neoadjuvant Therapy is a Predictor of Pathologic Response in Patients With Non-Small Cell Lung Cancer. Ann. Thorac. Surg.
78: 1903-1909
[Abstract][Full Text]
Antoch, G., Saoudi, N., Kuehl, H., Dahmen, G., Mueller, S. P., Beyer, T., Bockisch, A., Debatin, J. F., Freudenberg, L. S.
(2004). Accuracy of Whole-Body Dual-Modality Fluorine-18-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography and Computed Tomography (FDG-PET/CT) for Tumor Staging in Solid Tumors: Comparison With CT and PET. JCO
22: 4357-4368
[Abstract][Full Text]
Wong, C.-y. O., Salem, R., Qing, F., Wong, K. T., Barker, D., Gates, V., Lewandowski, R., Hill, E. A., Dworkin, H. J., Nagle, C.
(2004). Metabolic Response After Intraarterial 90Y-Glass Microsphere Treatment for Colorectal Liver Metastases: Comparison of Quantitative and Visual Analyses by 18F-FDG PET. JNM
45: 1892-1897
[Abstract][Full Text]
Schrevens, L., Lorent, N., Dooms, C., Vansteenkiste, J.
(2004). The Role of PET Scan in Diagnosis, Staging, and Management of Non-Small Cell Lung Cancer. The Oncologist
9: 633-643
[Abstract][Full Text]
Deserno, W. M. L. L. G., Harisinghani, M. G., Taupitz, M., Jager, G. J., Witjes, J. A., Mulders, P. F., Hulsbergen van de Kaa, C. A., Kaufmann, D., Barentsz, J. O.
(2004). Urinary Bladder Cancer: Preoperative Nodal Staging with Ferumoxtran-10-enhanced MR Imaging. Radiology
233: 449-456
[Abstract][Full Text]
Hillner, B. E., Tunuguntla, R., Fratkin, M.
(2004). Clinical Decisions Associated With Positron Emission Tomography in a Prospective Cohort of Patients With Suspected or Known Cancer at One United States Center. JCO
22: 4147-4156
[Abstract][Full Text]
Keidar, Z., Haim, N., Guralnik, L., Wollner, M., Bar-Shalom, R., Ben-Nun, A., Israel, O.
(2004). PET/CT Using 18F-FDG in Suspected Lung Cancer Recurrence: Diagnostic Value and Impact on Patient Management. JNM
45: 1640-1646
[Abstract][Full Text]
Cobben, D. C.P., Elsinga, P. H., Hoekstra, H. J., Suurmeijer, A. J.H., Vaalburg, W., Maas, B., Jager, P. L., Groen, H. M.J.
(2004). Is 18F-3'-Fluoro-3'-Deoxy-L-Thymidine Useful for the Staging and Restaging of Non-Small Cell Lung Cancer?. JNM
45: 1677-1682
[Abstract][Full Text]
Younes-Mhenni, S., Janier, M. F., Cinotti, L., Antoine, J. C., Tronc, F., Cottin, V., Ternamian, P. J., Trouillas, P., Honnorat, J.
(2004). FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes. Brain
127: 2331-2338
[Abstract][Full Text]
Cerfolio, R. J., Ojha, B., Bryant, A. S., Raghuveer, V., Mountz, J. M., Bartolucci, A. A.
(2004). The accuracy of integrated PET-CT compared with dedicated pet alone for the staging of patients with nonsmall cell lung cancer. Ann. Thorac. Surg.
78: 1017-1023
[Abstract][Full Text]
Aquino, S. L., Fischman, A. J.
(2004). Does Whole-Body 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Have an Advantage Over Thoracic Positron Emission Tomography for Staging Patients With Lung Cancer?. Chest
126: 755-760
[Abstract][Full Text]
Torabi, M., Aquino, S. L., Harisinghani, M. G.
(2004). Current Concepts in Lymph Node Imaging. JNM
45: 1509-1518
[Abstract][Full Text]
Lynch, T. J., Wright, C. D., Choi, N. C., Aquino, S. L., Mark, E. J.
(2004). Case 26-2004 - A 56-Year-Old Woman with Cough and a Lung Nodule. NEJM
351: 809-817
[Full Text]
Benamore, R. E, Entwisle, J. J, Peake, M. D
(2004). Bone scanning in lung cancer: Evidence is not sufficient to justify routine bone scanning. BMJ
329: 230-231
[Full Text]
Kramer, H, van Putten, J W G, Post, W J, van Dullemen, H M, Bongaerts, A H H, Pruim, J, Suurmeijer, A J H, Klinkenberg, T J, Groen, H, Groen, H J M
(2004). Oesophageal endoscopic ultrasound with fine needle aspiration improves and simplifies the staging of lung cancer. Thorax
59: 596-601
[Abstract][Full Text]
van Overhagen, H., Brakel, K., Heijenbrok, M. W., van Kasteren, J. H. L. M., van de Moosdijk, C. N. F., Roldaan, A. C., van Gils, A. P., Hansen, B. E.
(2004). Metastases in Supraclavicular Lymph Nodes in Lung Cancer: Assessment with Palpation, US, and CT. Radiology
232: 75-80
[Abstract][Full Text]
Viney, R. C., Boyer, M. J., King, M. T., Kenny, P. M., Pollicino, C. A., McLean, J. M., McCaughan, B. C., Fulham, M. J.
(2004). Randomized Controlled Trial of the Role of Positron Emission Tomography in the Management of Stage I and II Non-Small-Cell Lung Cancer. JCO
22: 2357-2362
[Abstract][Full Text]
Kramer, H., Pieterman, R. M., Slebos, D.-J., Timens, W., Vaalburg, W., Koeter, G. H., Groen, H. J.M.
(2004). PET for the Evaluation of Pleural Thickening Observed on CT. JNM
45: 995-998
[Abstract][Full Text]
Detterbeck, F. C., Falen, S., Rivera, M. P., Halle, J. S., Socinski, M. A.
(2004). Seeking a Home for a PET, Part 2: Defining the Appropriate Place for Positron Emission Tomography Imaging in the Staging of Patients With Suspected Lung Cancer. Chest
125: 2300-2308
[Abstract][Full Text]
Previous
