A Molecular Link between the Sudden Infant Death Syndrome and the Long-QT Syndrome
Peter J. Schwartz, M.D., Silvia G. Priori, M.D., Ph.D., Robert Dumaine, Ph.D., Carlo Napolitano, M.D., Ph.D., Charles Antzelevitch, Ph.D., Marco Stramba-Badiale, M.D., Ph.D., Todd A. Richard, M.S., Maria Rosaria Berti, M.D., and Raffaella Bloise, M.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
The sudden infant death syndrome (SIDS) remains the leadingcause of death in the first year of life and has a devastatingimpact on the affected families.1,2,3,4 Despite the fact thatthere have been many hypotheses,3,4 the cause or causes of SIDSare still uncertain; as a consequence, the only preventive measurerecommended is to avoid having infants sleep in a prone position.5
In 1998, we reported the results of a 19-year prospective studyof more than 34,000 infants who underwent electrocardiographyon the third or fourth day of life.6 We tested the hypothesis7,8that the congenital long-QT syndrome accounts . . . [Full Text of this Article]
Case Report
Methods
Molecular Screening
Gene-Expression Studies
Results
Molecular Screening
Gene-Expression Studies
Discussion
Source Information
From the Department of Cardiology, University of Pavia and Policlinico San Matteo Istituto di Ricovero e Cura a Carattere Scientifico, Pavia, Italy (P.J.S., S.G.P., R.B.); the Molecular Cardiology and Electrophysiology Laboratory, Fondazione Salvatore Maugeri Istituto di Ricovero e Cura a Carattere Scientifico, Pavia, Italy (S.G.P., C.N.); the Department of Molecular Biology, Masonic Medical Research Laboratory, Utica, N.Y. (R.D., C.A., T.A.R.); the Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy (C.N.); the Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Luca, Istituto Auxologico Italiano, Milan, Italy (M.S.-B.); and the Unità Operativa di Neonatologia, Ospedale S. Chiara, Trento, Italy (M.R.B.).
Address reprint requests to Dr. Schwartz at the Department of Cardiology, Policlinico San Matteo IRCCS, Viale Golgi, 19-27100 Pavia, Italy, or at pjqt@compuserve.com.
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