The immune system has traditionally been divided into innateand adaptive components, each with a different function androle. The adaptive component is organized around two classesof specialized cells, T cells and B cells. Since each lymphocytedisplays a single kind of structurally unique receptor, therepertoire of antigen receptors in the entire population oflymphocytes is very large and extremely diverse. The size anddiversity of this repertoire increase the probability that anindividual lymphocyte will encounter an antigen that binds toits receptor, thereby triggering activation and proliferationof the cell. This process, termed clonal selection, accounts. . . [Full Text of this Article]
Strategies of Innate and Adaptive Immune Recognition
Pattern-Recognition Receptors
Toll Receptors
Innate Immune Recognition and Control of Adaptive Immune Responses
Innate Immunity and Disease
Conclusions
Source Information
From the Section of Immunobiology, Yale University School of Medicine, New Haven, Conn.
Address reprint requests to Dr. Janeway at the Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, or to Dr. Medzhitov at ruslan@yale.edu.
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Sankaranarayanan, S., Untoro, J., Erhardt, J., Gross, R., Rosales, F. J.
(2004). Daily Iron Alone but Not in Combination with Multimicronutrients Increases Plasma Ferritin Concentrations in Indonesian Infants with Inflammation. J. Nutr.
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Ishihara, S., Rumi, M. A. K., Kadowaki, Y., Ortega-Cava, C. F., Yuki, T., Yoshino, N., Miyaoka, Y., Kazumori, H., Ishimura, N., Amano, Y., Kinoshita, Y.
(2004). Essential Role of MD-2 in TLR4-Dependent Signaling during Helicobacter pylori-Associated Gastritis. J. Immunol.
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Sivori, S., Falco, M., Chiesa, M. D., Carlomagno, S., Vitale, M., Moretta, L., Moretta, A.
(2004). CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: Induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc. Natl. Acad. Sci. USA
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Gomi, K., Tokue, Y., Kobayashi, T., Takahashi, H., Watanabe, A., Fujita, T., Nukiwa, T.
(2004). Mannose-Binding Lectin Gene Polymorphism Is a Modulating Factor in Repeated Respiratory Infections. Chest
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Lamkanfi, M., Kalai, M., Saelens, X., Declercq, W., Vandenabeele, P.
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Cuadros, C., Lopez-Hernandez, F. J., Dominguez, A. L., McClelland, M., Lustgarten, J.
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Baldwin, T., Henri, S., Curtis, J., O'Keeffe, M., Vremec, D., Shortman, K., Handman, E.
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Eisenbarth, S. C., Zhadkevich, A., Ranney, P., Herrick, C. A., Bottomly, K.
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Pickup, J. C.
(2004). Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes. Diabetes Care
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Chang, Y.-C., Hsu, T.-L., Lin, H.-H., Chio, C.-C., Chiu, A. W., Chen, N.-J., Lin, C.-H., Hsieh, S.-L.
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